Prognostic impact of anatomical extent of metastatic lymph node on gastric cancer: a propensity score matching study
Clin. transl. oncol. (Print)
; 23(4): 773-782, abr. 2021. graf
Article
in English
| IBECS
| ID: ibc-220913
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
Purpose Current gastric cancer staging systems overlook the anatomic extent of metastatic lymph nodes (AEMLNs). This study aimed to analyze the prognostic impact of AEMLNs on gastric cancer (GC). Methods GC patients with metastatic lymph nodes (MLNs) undergoing curative surgery were retrospectively reviewed and assigned to perigastric (MLNs in station 16, PG) and extraperigastric group (7-12, with or without MLNs in PG area, EPG). Overall survival (OS), disease-free survival (DFS) and recurrence patterns were compared before and after 11 propensity score matching (PSM). Results 662 patients were enrolled, 341 (51.5%) and 321 (48.5%) of whom were in the PG and EPG, respectively. After PSM (n = 195), EPG showed poorer 5-year OS (43.4% vs 54.5%, p = 0.014) and DFS (65.0% vs 73.4%, p = 0.068) than PG. EPG had higher incidence of peritoneal recurrence (PR) than PG (19.4% vs 7.4%, p = 0.002). Multivariate analysis identified AEMLNs as prognostic factor for OS [HR = 1.409, 95% confidence interval (CI) 1.0621.868), DFS (HR = 1.600, 95% CI 1.0592.416) and PR (HR = 3.708, 95% CI 1.6858.160). Conclusions The anatomic extent of metastatic lymph nodes has an independent prognostic role for GC. Including this element may improve the accuracy of current staging systems (AU)
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Stomach Neoplasms
/
Lymph Nodes
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Clin. transl. oncol. (Print)
Year:
2021
Document type:
Article
Institution/Affiliation country:
Sun Yat-sen University/China