Use of nimotuzumab combined with cisplatin in treatment of nasopharyngeal carcinoma and its effect on expressions of VEGF and MMP-2
Clin. transl. oncol. (Print)
; 23(7): 1342-1349, jul. 2021. graf
Article
in English
| IBECS
| ID: ibc-221974
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
Purpose This paper aims to observe the expressions of VEGF and MMP-2 in patients with nasopharyngeal carcinoma treated by nimotuzumab combined with cisplatin. Methods Altogether, 104 patients with nasopharyngeal carcinoma treated in our hospital from April 2014 to August 2016 were selected as research subjects. Among them, 50 patients treated with cisplatin were divided into a control group and 54 patients treated with nimotuzumab combined with cisplatin were divided into an observation group. The two groups of patients were compared in terms of efficacy after treatment and incidence of adverse reactions. Changes of serum VEGF and MMP-2 concentrations before and after treatment were detected using enzyme-linked immunosorbent assay (ELISA), and the 3-year overall survival (OS) of patients was observed. Results Compared with the control group, patients in the observation group had significantly higher total remission rate (RR) (P < 0.05) and significantly lower incidence of adverse reactions (P < 0.05). Before treatment, there was no significant difference between the observation and control groups in the concentrations of VEGF and MMP-2 (P > 0.05). After treatment, the concentrations in the two groups were significantly lower than those before treatment (P < 0.05), and the concentrations in the observation group were significantly lower than those in the control group (P < 0.05). There was no significant difference in the 3-year OS between the observation and control groups (P > 0.05). Conclusions Nimotuzumab combined with cisplatin could improve the conditions of patients with nasopharyngeal carcinoma. After treatment, the expression of VEGF and MMP-2 decreased significantly. We speculated that it improves the survival rate of patients by reducing the expression of VEGF and MMP-2 (AU)
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Antineoplastic Combined Chemotherapy Protocols
/
Nasopharyngeal Neoplasms
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Cisplatin
/
Matrix Metalloproteinase 2
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Vascular Endothelial Growth Factor A
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Antibodies, Monoclonal, Humanized
Limits:
Adult
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Female
/
Humans
/
Male
Language:
English
Journal:
Clin. transl. oncol. (Print)
Year:
2021
Document type:
Article
Institution/Affiliation country:
ECG Room, Zhangqiu District Peoples Hospital/Peoples Republic of China
/
Yantai Yuhuangding Hospital/ Peoples Republic of China
/
Yantaishan Hospital/Peoples Republic of China
/
Zhangqiu District Peoples Hospital/Peoples Republic of China