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Moderate hypofractionated post-prostatectomy radiation therapy is feasible and well tolerated: experience from a single tertiary cancer centre
Valero, J; Montero, A; Hernando, O; Izquierdo, M; Sánchez, E; García-Aranda, M; López, M; Ciérvide, R; Álvarez, B; Alonso, RV.
Affiliation
  • Valero, J; HM Hospitales. Hospital Universitario HM Sanchinarro. Department of Radiation Oncology. Madrid. Spain
  • Montero, A; HM Hospitales. Hospital Universitario HM Sanchinarro. Department of Radiation Oncology. Madrid. Spain
  • Hernando, O; HM Hospitales. Hospital Universitario HM Sanchinarro. Department of Radiation Oncology. Madrid. Spain
  • Izquierdo, M; HM Hospitales. Hospital Universitario HM Sanchinarro. Department of Radiation Oncology. Madrid. Spain
  • Sánchez, E; HM Hospitales. Hospital Universitario HM Sanchinarro. Department of Radiation Oncology. Madrid. Spain
  • García-Aranda, M; HM Hospitales. Hospital Universitario HM Sanchinarro. Department of Radiation Oncology. Madrid. Spain
  • López, M; HM Hospitales. Hospital Universitario HM Sanchinarro. Department of Radiation Oncology. Madrid. Spain
  • Ciérvide, R; HM Hospitales. Hospital Universitario HM Sanchinarro. Department of Radiation Oncology. Madrid. Spain
  • Álvarez, B; HM Hospitales. Hospital Universitario HM Sanchinarro. Department of Radiation Oncology. Madrid. Spain
  • Alonso, RV; HM Hospitales. Hospital Universitario HM Sanchinarro. Department of Radiation Oncology. Madrid. Spain
Clin. transl. oncol. (Print) ; 23(7): 1452-1462, jul. 2021. ilus
Article in English | IBECS | ID: ibc-221985
Responsible library: ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
Purpose Conventional post-prostatectomy radiation therapy comprises 6.5–8 weeks of treatment, therefore, hypofractionated and shortened schemes arouse increasing interest. We describe our experience regarding feasibility and clinical outcome of a post-prostatectomy moderate hypofractionated image-guided radiotherapy schedule Materials and methods From Oct 2015–Mar 2020, 113 patients, median age of 62 years-old (range 45–76) and prostate adenocarcinoma of low risk (30%), intermediate risk (49%) and high risk (21%) were included for adjuvant (34%) or salvage radiation therapy (66%) after radical prostatectomy (RP). All patients underwent radiotherapy with image-guided IMRT/VMAT to a total dose of 62.5 Gy in 2.5 Gy/fraction in 25 fractions. Sixteen patients (14%) received concomitant androgen deprivation therapy. Results With a median follow-up of 29 months (range 3–60 months) all patients but three are alive. Eleven patients (10%) developed exclusive biochemical relapse while 19 patients (17%) presented macroscopically visible relapse prostatectomy bed in two patients (2%), pelvic lymph nodes in 13 patients (11.5%) and distant metastases in four patients (4%). The 3 years actuarial rates for OS, bFRS, and DMFS were 99.1, 91.1 and 91.2%, respectively. Acute and late tolerance was satisfactory. Maximal acute genitourinary (AGU) toxicity was G2 in 8% of patients; maximal acute gastrointestinal (AGI) toxicity was G2 in 3.5% of patients; maximal late genitourinary (LGU) toxicity was G3 in 1% of patients and maximal late gastrointestinal (LGI) toxicity was G2 in 2% of patients. There were no cases of severe acute or late toxicity. No relationship was found between acute or late GI/GU adverse effects and dosimetric parameters, age, presence of comorbidities or concomitant treatments (AU)
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Collection: National databases / Spain Database: IBECS Main subject: Prostatectomy / Prostatic Neoplasms / Radiation Dose Hypofractionation Limits: Aged / Humans / Male Language: English Journal: Clin. transl. oncol. (Print) Year: 2021 Document type: Article Institution/Affiliation country: HM Hospitales/Spain
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Collection: National databases / Spain Database: IBECS Main subject: Prostatectomy / Prostatic Neoplasms / Radiation Dose Hypofractionation Limits: Aged / Humans / Male Language: English Journal: Clin. transl. oncol. (Print) Year: 2021 Document type: Article Institution/Affiliation country: HM Hospitales/Spain
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