The role of brachytherapy (interventional radiotherapy) for primary and/or recurrent vulvar cancer: a Gemelli Vul. Can multidisciplinary team systematic review
Clin. transl. oncol. (Print)
; 23(8): 1611-1619, ago. 2021.
Article
in En
| IBECS
| ID: ibc-222160
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
Objective The aim of our systematic review was to assess the role of interventional radiotherapy (IRT, brachytherapy) in the management of primary and/or recurrent vulvar carcinoma. Evidence acquisition A systematic research using PubMed, Scopus and Cochrane library was performed. ClinicalTrials.gov was searched for ongoing or recently completed trials, and PROSPERO was searched for ongoing or recently completed systematic reviews. Only full-text English-language articles related to IRT for treatment of primary or recurrent VC were identified and reviewed. Conference paper, survey, letter, editorial, book chapter and review were excluded. Time restriction (19902018) as concerns the years of the publication was considered. Evidence synthesis Primary disease: the median 5-year LC was 43.5% (range 1968%); the median 5-year DFS was 44.5% (range 4481%); the median 5-year OS was 50.5% (range 2785%). Recurrent disease: the median 5-year DFS was 64% (range 5672%) and the median 5-year OS was 45% (range 33%-57%). Acute ≥ grade 2 toxicity was reported in three patients (1.6%). The severe late toxicity rates (grade 34) ranged from 0% to 14.3% (median 7.7%). Conclusion IRT as part of primary treatment for primary and/or recurrent vulvar cancer is associated with promising clinical outcomes (AU)
Key words
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Collection:
06-national
/
ES
Database:
IBECS
Main subject:
Vulvar Neoplasms
/
Brachytherapy
Limits:
Adult
/
Aged
/
Female
/
Humans
Language:
En
Journal:
Clin. transl. oncol. (Print)
Year:
2021
Document type:
Article