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Polygenic risk of bone fractures in Spanish women with osteoporosis / Riesgo poligénico de fracturas óseas en mujeres españolas con osteoporosis
Real, Álvaro del; Olmos Martínez, José Manuel; Hernández, José L; Madrid, Carmen Valero Díaz de la; Riancho Moral, José Antonio; Cruz, Raquel.
Affiliation
  • Real, Álvaro del; Universidad de Cantabria. Department of Medicine and Psychiatry. Santander. Spain
  • Olmos Martínez, José Manuel; Universidad de Cantabria. Department of Medicine and Psychiatry. Santander. Spain
  • Hernández, José L; Universidad de Cantabria. Department of Medicine and Psychiatry. Santander. Spain
  • Madrid, Carmen Valero Díaz de la; Universidad de Cantabria. Department of Medicine and Psychiatry. Santander. Spain
  • Riancho Moral, José Antonio; Universidad de Cantabria. Department of Medicine and Psychiatry. Santander. Spain
  • Cruz, Raquel; Universida de de Santiago de Compostela. Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER). Santiago de Compostela. Spain
Rev. osteoporos. metab. miner. (Internet) ; 15(2): 66-71, Abr-Jun 2023. tab, graf
Article in English | IBECS | ID: ibc-222674
Responsible library: ES1.1
Localization: ES15.1 - BNCS
ABSTRACT

Background:

osteoporosis is a highly polygenic trait characterized by low bone mineral density (BMD) and/or fragility frac-tures. Over the past decade, polygenic risk scores (PRS) are an emerging tool to try to predict the risk of complex disorderswith a genetic component.

Objective:

to analyze the capacity of different PRSs to predict osteoporosis in the Spanish population.Material and

methods:

our dataset consisted of two differentiated groups. The first group included osteoporosis casesdiagnosed and treated at the Marques de Valdecilla University Hospital (n = 304; 293 women) while the second groupconsisted of people from the overall Spanish population (n = 3199; 1458 women). Four previously generated PRSs werecompared with generalized linear models.

Results:

the osteoporosis group showed a significantly higher genetic risk compared to the control group in 3 PRSs (PRS-1p = 1e-7; PRS-2 p = 1.87e-15; PRS-3 p = 0.1477; PRS-4 p = 8.98e-9). In addition, in these PRSs, the individuals in the upperquartile of risk had a significantly higher risk of osteoporosis, compared to those individuals in the other quartiles (PRS-1OR, 1.83; PRS-2 OR, 2.11; PRS-3 OR, 0.96; PRS-4 OR, 1.72).

Conclusions:

in summary, the application of PRSs shows significant differences between the overall Spanish populationand patients with osteoporosis, which is suggestive of its utility within strategies for the identification of subjects at riskbased on clinical-genetic criteria.(AU)
Subject(s)


Full text: Available Collection: National databases / Spain Database: IBECS Main subject: Bone Density / Multifactorial Inheritance / Fractures, Bone / Frailty Limits: Female / Humans Country/Region as subject: Europa Language: English Journal: Rev. osteoporos. metab. miner. (Internet) Year: 2023 Document type: Article Institution/Affiliation country: Universida de de Santiago de Compostela/Spain / Universidad de Cantabria/Spain

Full text: Available Collection: National databases / Spain Database: IBECS Main subject: Bone Density / Multifactorial Inheritance / Fractures, Bone / Frailty Limits: Female / Humans Country/Region as subject: Europa Language: English Journal: Rev. osteoporos. metab. miner. (Internet) Year: 2023 Document type: Article Institution/Affiliation country: Universida de de Santiago de Compostela/Spain / Universidad de Cantabria/Spain
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