Survival and prognostic factors in patients with oral squamous cell carcinoma / Supervivencia y factores pronósticos en pacientes con carcinoma oral de células escamosas
Med. oral patol. oral cir. bucal (Internet)
; 26(3): e387-e392, May. 2021. graf, tab
Article
in English
| IBECS
| ID: ibc-224564
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
Background:
This study aimed to evaluate sociodemographic and clinical factors influencing overall survival(OS) in patients with oral squamous cell carcinoma (OSCC).Material andMethods:
Medical charts of 547 patients with OSCC from a public hospital in northeastern Brazilseen between 1999 and 2013 were evaluated. Survival analysis was performed using the Kaplan-Meier method.The influence of age, sex, ethnicity, clinical stage, anatomical location, type of treatment, and comorbidities on thepatients prognosis was evaluated. Cox proportional hazards regression model was used to identify independentprognostic factors.Results:
The 5-year OS was 39%. Multivariate analysis showed that age < 40 years (HR = 2.20; 95%CI 1.02-4.72)and a single treatment modality (HR = 1.91; 95%CI 1.37-2.67) were associated with a poor prognosis, while earlyclinical stage resulted in better outcomes (HR = 0.38; 95%CI 0.25-0.58).Conclusions:
OSCC patients in advanced clinical stages, diagnosed at a younger age, and submitted to a singletherapeutic modality have a poorer prognosis.(AU)
Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Carcinoma, Squamous Cell
/
Medical Records
/
29161
/
Survivorship
/
Head and Neck Neoplasms
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Med. oral patol. oral cir. bucal (Internet)
Year:
2021
Document type:
Article
Institution/Affiliation country:
Universidade Estadual da Paraíba (UEPB)/Brazil
/
Universidade Federal de Minas Gerais (UFMG)/Brazil
/
Universidade Federal de Pernambuco (UFPE)/Brazil