Oral food challenge in children with contact urticaria in reaction to cows milk
Allergol. immunopatol
; 51(5)01 sept. 2023. ilus
Article
in English
| IBECS
| ID: ibc-225052
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
Objective:
To evaluate the relationship between the occurrence of contact urticaria in reaction to cows milk in infants and the diagnosis of cows milk allergy (CMA) established by supervised oral food challenge.Methods:
In this cross-sectional study, we identified 184 children who had undergone 221 oral food challenge (OFC) at a CMA reference center between July 2015 and August 2019. Of these, 23 (12.5%) had a history of contact urticaria to cows milk and underwent a total of 30 OFC. Baked cows milk OFC were excluded, and 21 children were included in the study. All data from clinical history and allergy tests (serum-specific IgE dosages and skin prick test [SPT] with reconstituted cows milk formula) were recorded on standardized forms. The challenge was conducted with reconstituted cows milk formula in increasing volumes every 1520 min.Results:
24 OFC were performed; 13/24 (54.2%) for diagnostic purpose and 11/24 (45.8%) to evaluate cows milk tolerance. Allergy tests were positive in 14 patients (87.5%). Positive oral challenge outcomes were identified in 7/24. One patient had a late flare of atopic dermatitis and five children presented with immediate urticaria (two generalized urticaria and three perioral urticaria). The median papule diameter was 6.5 mm in patients with a positive OFC and 3.75 mm in the negative group (P = 0.02).Conclusion:
The occurrence of contact urticaria might be the only manifestation among infants sensitized to cows milk with tolerance to oral ingestion. Reactions due to oral challenge were related to a larger wheal diameter on the SPT (AU)
Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Urticaria
/
Milk Hypersensitivity
Limits:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Language:
English
Journal:
Allergol. immunopatol
Year:
2023
Document type:
Article
Institution/Affiliation country:
Federal University of Paraná/Brazil
/
Positivo University/Brazil