Induction of perineural invasion in salivary adenoid cystic carcinoma by circular RNA RNF111
Clin. transl. oncol. (Print)
; 25(11): 3152-3164, 11 nov. 2023. graf
Article
in English
| IBECS
| ID: ibc-226840
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
Objective Local recurrence, distant metastasis, and perineural invasion (PNI) viciously occur in salivary adenoid cystic carcinoma (SACC), resulting in a poor prognosis. This study aimed to explore the mechanism by which circular RNA RNF111 (circ-RNF111) regulates PNI in SACC by targeting the miR-361-5p/high mobility group box 2 (HMGB2) axis. Method Circ-RNF111 and HMGB2 were highly expressed in SACC specimens, while miR-361-5p was underexpressed. Functional experiments showed that ablating circ-RNF111 or promoting miR-361-5p hindered the biological functions and PNI of SACC-LM cells. Results HMGB2 overexpression induced the reversal of SACC-LM cell biological functions and PNI caused by circ-RNF111 knockout. Furthermore, reduction of circ-RNF111 suppressed PNI in a SACC xenograft model. Circ-RNF111 regulated HMGB2 expression through targeted modulation of miR-361-5p. Conclusion Taken together, circ-RNF111 stimulates PNI in SACC by miR-361-5p/HMGB2 axis and may serve as a potential therapeutic target for SACC (AU)
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Salivary Gland Neoplasms
/
Carcinoma, Adenoid Cystic
/
HMGB2 Protein
/
MicroRNAs
Limits:
Humans
Language:
English
Journal:
Clin. transl. oncol. (Print)
Year:
2023
Document type:
Article
Institution/Affiliation country:
Longyan Peoples Hospital/China