Network pharmacology analysis of Yi-Shen-Gu-Ta i-Ke-Li for recurrent spontaneous abortion in female fitness and athletic populations
Rev. int. med. cienc. act. fis. deporte
; 23(91): 293-320, jul. 2023. ilus, graf, tab
Article
in En
| IBECS
| ID: ibc-226932
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
Background: Yi-Shen-Gu-Tai-Ke-Li (YSGTKL), a renowned traditional herbal formula, has demonstrated clinical efficacy in addressing recurrent spontaneous abortion (RSA). Despite its widespread utilization in China, the current body of evidence regarding the effectiveness of its herbal components remains insufficient, and the underlying mechanisms of action remain enigmatic. This study endeavors to unravel the mechanisms responsible for the therapeutic effectiveness of YSGTKL in treating RSA, particularly within the context of female fitness and athletic populations. Methods: YSGTKL comprises various herbal plants, selected based on the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). Specific drug targets associated with RSA were meticulously identified and corroborated using multiple reputable sources, including DrugBank, GeneCards, and Online Mendelian Inheritance in Man. The GEO database was leveraged to pinpoint differentially expressed genes (DEGs) relevant to RSA within female fitness and athletic populations. Subsequently, a comprehensive drug-compound-gene-disease network was meticulously constructed and visualized using Cytoscape software. Functional insights were gleaned through Gene Ontology (GO) annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. Within this network, a subset of hub genes was discerned through a protein-protein interaction (PPI) network analysis, specifically tailored to female fitness and athletic populations. To validate key active ingredients and core targets, molecular docking analyses were meticulously performed, taking into account the unique physiological aspects of female athletes and fitness enthusiasts. (AU).
Key words
Full text:
1
Collection:
06-national
/
ES
Database:
IBECS
Main subject:
Drugs, Chinese Herbal
/
Abortion, Habitual
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Athletes
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Medicine, Chinese Traditional
Limits:
Adult
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Female
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Humans
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Pregnancy
Language:
En
Journal:
Rev. int. med. cienc. act. fis. deporte
Year:
2023
Document type:
Article