Role of sonic hedgehog signaling pathway in the regulation of ion channels: focus on its association with cardio-cerebrovascular diseases
J. physiol. biochem
; 79(4): 719-730, nov. 2023. ilus
Article
in English
| IBECS
| ID: ibc-227547
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
Sonic hedgehog (SHH) signaling is vital for cell differentiation and proliferation during embryonic development, yet its role in cardiac, cerebral, and vascular pathophysiology is under debate. Recent studies have demonstrated that several compounds of SHH signaling regulate ion channels, which in turn affect the behavior of target cells. Some of these ion channels are involved in the cardio-cerebrovascular system. Here, we first reviewed the SHH signaling cascades, then its interaction with ion channels, and their impact on cardio-cerebrovascular diseases. Considering the complex cross talk of SHH signaling with other pathways that also affect ion channels and their potential impact on the cardio-cerebrovascular system, we highlight the necessity of thoroughly studying the effect of SHH signaling on ion homeostasis, which could serve as a novel mechanism for cardio-cerebrovascular diseases. (AU)
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Cerebrovascular Disorders
/
Hedgehog Proteins
Limits:
Female
/
Humans
/
Pregnancy
Language:
English
Journal:
J. physiol. biochem
Year:
2023
Document type:
Article
Institution/Affiliation country:
Central South University/China
/
The Third Xiangya Hospital of Central South University/China