Dose-response effects of exercise on mental health in community-dwelling older adults: Exploration of genetic moderators / Efectos dosis-respuesta del ejercicio sobre la salud mental en adultos mayores que viven en la comunidad: exploración de moderadores genéticos
Int. j. clin. health psychol. (Internet)
; 24(1): [100443], Ene-Mar, 2024. tab, graf
Article
in English
| IBECS
| ID: ibc-230382
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
Background/Objective:
(1) Examine the role of exercise intensity on mental health symptoms in a community-based sample of older adults. (2) Explore the moderating role of genetic variation in brain-derived neurotrophic factor (BDNF) and apolipoprotein E (APOE) on the effects of exercise on mental health symptoms.Method:
This study is a secondary analysis of a three-arm randomized controlled trial, comparing the effects of 6 months of high-intensity aerobic training vs. moderate-intensity aerobic training vs. a no-contact control group on mental health symptoms assessed using the Depression, Anxiety, and Stress Scale (DASS). The BDNF Val66Met polymorphism and APOE ε4 carrier status were explored as genetic moderators of exercise effects on mental health symptoms.Results:
The exercise intervention did not influence mental health symptoms. The BDNF Val66Met polymorphism did not moderate intervention effects on mental health symptoms. APOE ε4 carrier status moderated the effect of intervention group on perceived stress over 6 months, such that APOE ε4 carriers, but not non-carriers, in the high-intensity aerobic training group showed a decline in perceived stress over 6 months.Conclusions:
APOE ε4 carrier status may modify the benefits of high-intensity exercise on perceived stress such that APOE ε4 carriers show a greater decline in stress as a result of exercise relative to non-APOE ε4 carriers.(AU)
Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Anxiety
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Stress, Psychological
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Cognitive Behavioral Therapy
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Mental Health
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Cognition
Limits:
Adult
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Female
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Humans
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Male
Language:
English
Journal:
Int. j. clin. health psychol. (Internet)
Year:
2024
Document type:
Article
Institution/Affiliation country:
AdventHealth Research Institute/USA
/
Edith Cowan University/Australia
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Indianapolis University/USA
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Murdoch University/Australia
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University of Pittsburgh/USA