Quantitative immunohistochemical expression of GP88 in invasive ductal carcinoma (IDC) of human breast cancer
Iberoam. j. med
; 3(1)feb. 2021. ilus, tab, graf
Article
in English
| IBECS
| ID: ibc-230973
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
Introduction:
Progranulin or acrogranin is an 88-kDa glycoprotein identified by a biological screen for protein targets associated with high tumorigenicity. This work was aimed to investigate the digital expression of GP88, and HER2/neu as a predictive biomarker in human invasive ductal carcinoma (IDC) versus benign tumors and normal breast tissues, as well as its correlation with different pathological parameters.Methods:
The immunohistochemical avidin-biotin complex protocol of the paraffin section was used to detect the expression of GP88 and HER2/neu in IDC of 60 patients, 30 benign, and ten normal breast tissues.Results:
The study showed a high expression of GP88 in IDC comparing to normal and benign breast tissues. A higher significant statistical correlation between the expression of GP88 and large tumor size, tumor grade, and lymph node metastasis (LNM). While a negative statistical correlation was noticed between the expression of GP88 and ER, PR, and HER2/neu status.Discussion:
The results of the quantitative immunostaining density of GP88 glycoprotein antibody revealed it to be a valuable predictive and therapeutic marker of GP88 in human IDC patients (AU)
Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Breast Neoplasms
/
Glycoproteins
/
Carcinoma, Ductal, Breast
Limits:
Female
/
Humans
Language:
English
Journal:
Iberoam. j. med
Year:
2021
Document type:
Article
Institution/Affiliation country:
Alexandria University/Egypt
/
Sana'a University/Republic of Yemen