Antibiomania: A Case Report of a Manic Episode Potentially Induced by the Interaction of Clarithromycin and Amoxicillin during H. Pylori Eradication Therapy
Actas esp. psiquiatr
; 52(1): 57-59, Feb. 2024.
Article
in English
| IBECS
| ID: ibc-231257
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
Antibiomanic episodes, or as the DSM-5 refers to them, drug-induced manic episodes, pose a clinical challenge that is still poorly understood. There is insufficient information on the most common clinical presentation, patient profile, or underlying aetiopathogenic mechanisms. We present the clinical case of a 67-year-old woman who, after starting treatment (clarithromycin and amoxicillin) for the eradication of Helicobacter pylori, bacteria presented with a brief manic episode, which resolved after withdrawal of both drugs and with antipsychotic treatment. The possible interaction of both drugs, as GABA antagonists, in the generation of such episodes is discussed, and the clinical importance of such episodes in psychiatric emergency departments and liaison and interconsultation psychiatry, is highlighted. (AU)
Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Bipolar Disorder
/
Clarithromycin
/
Drug Interactions
/
Amoxicillin
Limits:
Aged
/
Female
/
Humans
Language:
English
Journal:
Actas esp. psiquiatr
Year:
2024
Document type:
Article
Institution/Affiliation country:
Hospital Clínico Universitario de Valencia/Spain