Hepatosplenic T-cell lymphoma and inflammatory bowel disease
Rev. esp. enferm. dig
; 116(3): 175-176, 2024.
Article
in English
| IBECS
| ID: ibc-231490
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
A 48-year-old man with a diagnosis of ulcerative colitis 18 years ago, under immunosuppressive treatment with azathioprine in the last 6 years due to corticosteroid dependence, was admitted to the Emergency Department due to fever of one weeks evolution. Blood tests showed thrombocytopenia, CRP 96.9mg/L, ferritin 3021ng/mL and hypertriglyceridemia. Blood and urine cultures were negative. Viral serologies (hepatitis B and C, HIV, parvovirus, CMV, HSV), atypical bacteria (Borrelia, Chlamydia, Coxiella) and screening for latent tuberculosis were also negative. Thoracoabdominal CT scan only showed splenomegaly. The bone marrow aspirate revealed immature lymphoid cells and a hemophagocyte figure, fulfilling the criteria for hemophagocytic syndrome, starting corticosteroid therapy at a dose of 1mg/Kg. Subsequently, the existence of an intrasinusoidal CD3 + CD5- lymphoid infiltrate and a FISH study with isochromosome 7q was reported, a characteristic pattern of hepatosplenic T-cell lymphoma (HSTCL). The study was completed with liver biopsy appreciating a 70% infiltration of T lymphocytes (50% gamma-delta) therefore the diagnosis was confirmed. Chemotherapy (cyclophosphamide, doxorubicin, vincristine, etoposide) was started with the aim of considering hematopoietic stem cell transplantation. Unfortunately, the patient died 6 months later. (AU)
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Inflammatory Bowel Diseases
/
Lymphoma, T-Cell
Limits:
Humans
/
Male
Language:
English
Journal:
Rev. esp. enferm. dig
Year:
2024
Document type:
Article
Institution/Affiliation country:
Hospital Universitari Germans Trias i Pujol/Spain