Predictors of transition to schizophrenia and other long-lasting non-affective psychoses in first-episode patients with acute and transient psychotic disorders: A validation study
Eur. j. psychiatry
; 38(2): [100234], Apr.-Jun. 2024.
Article
in English
| IBECS
| ID: ibc-231862
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
Background and objectives Almost half of the individuals with a first-episode of psychosis who initially meet criteria for acute and transient psychotic disorder (ATPD) will have had a diagnostic revision during their follow-up, mostly toward schizophrenia. This study aimed to determine the proportion of diagnostic transitions to schizophrenia and other long-lasting non-affective psychoses in patients with first-episode ATPD, and to examine the validity of the existing predictors for diagnostic shift in this population. Methods We designed a prospective two-year follow-up study for subjects with first-episode ATPD. A multivariate logistic regression analysis was performed to identify independent variables associated with diagnostic transition to persistent non-affective psychoses. This prediction model was built by selecting variables on the basis of clinical knowledge. Results Sixty-eight patients with a first-episode ATPD completed the study and a diagnostic revision was necessary in 30 subjects at the end of follow-up, of whom 46.7% transited to long-lasting non-affective psychotic disorders. Poor premorbid adjustment and the presence of schizophreniform symptoms at onset of psychosis were the only variables independently significantly associated with diagnostic transition to persistent non-affective psychoses. Conclusion Our findings would enable early identification of those inidividuals with ATPD at most risk for developing long-lasting non-affective psychotic disorders, and who therefore should be targeted for intensive preventive interventions. (AU)
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Psychotic Disorders
/
Schizophrenia
/
Predictive Value of Tests
/
Forecasting
Limits:
Adult
/
Aged
Country/Region as subject:
Europa
Language:
English
Journal:
Eur. j. psychiatry
Year:
2024
Document type:
Article
Institution/Affiliation country:
San Juan de la Cruz Hospital/Spain
/
University of Seville/Spain
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Virgen Macarena University Hospital/Spain