Fulminant hepatitis due to spontaneous reactivation of virus B in an immunocompetent patient
Rev. esp. enferm. dig
; 116(4): 232-233, 2024. tab
Article
in English
| IBECS
| ID: ibc-232476
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
We present the case of a 52-year-old woman with a history of HBeAg-negative chronic hepatitis B virus (HBV) infection, viral load (VL) Z+<20,000U.l/ml with no evidence of liver fibrosis and, therefore, untreated. She presented to the emergency department with jaundice, epigastric pain, nausea, and vomiting. On admission, blood analysis revealed ALT 3982U/l, AST 3221U/l, Gamma-GT 80U/l, alkaline phosphatase 252U/l, LDH 960U/l, bilirrubin12.5mg/dl; no elevation of acute phase reactants, 141,000 platelets and coagulopathy with a prothrombin activity of 29%. Abdominal ultrasound showed no relevant findings. The serological profile revealed AgHBs+, anti-HBe+ y anti-HBc IgM+ and VL VHB>100 mills. Ul/ml, the remaining serology was negative and other causes of liver disease were ruled out. With the diagnosis of severe acute hepatitis (SAH) due to HBV reactivation (HBVR) treatment with entecavir was initiated. Given the analytical evolution (Table 1) and the appearance of encephalopathy grade I-II/IV, an urgent liver transplant was performed. The histological result of the explant was conclusive with intense interphase and lobular hepatitis with extensive areas of massive necrosis in both lobes, without hepatic fibrosis compatible with fulminant hepatitis (FH). (AU)
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Hepatitis B virus
/
Liver Transplantation
/
Immunocompromised Host
/
Hepatitis B
Limits:
Female
/
Humans
Language:
English
Journal:
Rev. esp. enferm. dig
Year:
2024
Document type:
Article
Institution/Affiliation country:
Hospital Universitario 12 de Octubre/Spain