Interleucina-8 en el lavado broncoalveolar del donante y su impacto en la disfunción primaria del injerto en el trasplante bipulmonar / Interleukin 8 Concentrations in Donor Bronchoalveolar Lavage: Impact on Primary Graft Failure in Double Lung Transplant

RESUMEN

La disfunción primaria del injerto pulmonar (DPIP) contin¨²a siendo la principal causa de mortalidad perioperatoria y precoz en los receptores de un trasplante pulmonar (TP)1. La DPIP es una lesi¨®n pulmonar aguda, que acontece en el per ...(AU)

ABSTRACT

Background and Objective The purpose of this study was to determine concentrations of interleukin 8 (IL-8) in the bronchoalveolar lavage (BAL) fluid from donor lungs and assess the role of IL-8 levels in the development of primary graft failure.Patients and MethodTwenty patients who received a double lung transplant were studied. A series of data, including BAL fluid concentrations of IL-8, were collected for the donors. Data collected for the recipients included arterial blood gases after 6, 24, and 48hours, and intubation time. Patients with a ratio of PaO2 to the fraction of inspired oxygen (FiO2) of less than 300 during the first 48hours were diagnosed with primary graft failure. IL-8 levels were determined by enzyme-linked immunosorbent assay. Associations between the donor variables and IL-8 concentrations were evaluated using the Spearman rank correlation coefficient (¦Ñ) and the Mann-Whitney test for categorical and continuous variables, respectively. Logistic regression was used for multivariate analysis(AU)