Your browser doesn't support javascript.
loading
The effect of in vitro ã-irradiation on mitogenic responsiveness of murine lymphocytes
Hernández-Godoy, J; Planelles, D; Balsalobre, B; González-Molina, A.
Affiliation
  • Hernández-Godoy, J; Hospital La Fe. Unidad de Inmunología Experimental. Centro de Investigación. Valencia. Spain
  • Planelles, D; Hospital La Fe. Unidad de Inmunología Experimental. Centro de Investigación. Valencia. Spain
  • Balsalobre, B; Hospital La Fe. Unidad de Inmunología Experimental. Centro de Investigación. Valencia. Spain
  • González-Molina, A; Hospital La Fe. Unidad de Inmunología Experimental. Centro de Investigación. Valencia. Spain
J. physiol. biochem ; 64(3): 179-188, jul.-sept. 2008. tab, graf
Article in English | IBECS | ID: ibc-61822
Responsible library: ES1.1
Localization: BNCS
ABSTRACT
The objective of this study was to analyze the proliferative response of BALB/cmice lymphocytes after in vitro irradiation (0.05 to 6 Gy). The capability of irradiatedlymphocytes for proliferating without any stimulation and after activation withspecific T and B cell mitogens has been evaluated. The results show that ionizingradiation significantly inhibits spontaneous cellular proliferation and that induced bymitogens and that variations in the degree of inhibition are found depending on theinducing proliferation mitogens and the dosage applied. The conclusion drawn is thatdifferent lymphocyte populations have different radiosensitivities, being B cells moresensitive to ionizing irradiation than T cells. Besides, the effects of gamma-irradiationvary according to the different subpopulations of T cells or, alternatively, to differentT-dependent activation mechanisms (AU)
RESUMEN
No disponible
Subject(s)
Search on Google
Add to My VHL
Print
XML
Collection: National databases / Spain Database: IBECS Main subject: Phytohemagglutinins / Radiation Tolerance / Lipopolysaccharides / B-Lymphocyte Subsets / T-Lymphocyte Subsets / Concanavalin A / Cell Proliferation / Dose-Response Relationship, Immunologic / Mitogens Limits: Animals Language: English Journal: J. physiol. biochem Year: 2008 Document type: Article Institution/Affiliation country: Hospital La Fe/Spain
Search on Google
Add to My VHL
Print
XML
Collection: National databases / Spain Database: IBECS Main subject: Phytohemagglutinins / Radiation Tolerance / Lipopolysaccharides / B-Lymphocyte Subsets / T-Lymphocyte Subsets / Concanavalin A / Cell Proliferation / Dose-Response Relationship, Immunologic / Mitogens Limits: Animals Language: English Journal: J. physiol. biochem Year: 2008 Document type: Article Institution/Affiliation country: Hospital La Fe/Spain