Is allergenic similarity predictable in respiratory allergies?
Allergol. immunopatol
; 36(2): 59-65, abr. 2008. tab
Article
in En
| IBECS
| ID: ibc-64436
Responsible library:
ES15.1
Localization: ES15.1 - BNCS
ABSTRACT
Background:
First degree relatives of patients with allergic diseases are at increased risk of having the disorder. However, it is not clear whether two such related patients with allergic diseases are sensitive to the same antigens or not.Objective:
The aim of this study to determine whether or not first degree relatives with respiratory allergies are more likely to be skin test positive to the same allergen extracts as unrelated patients. Patients andMethods:
Skin test results for 35 common aeroallergens were compared in 264 pairs of genetically related subjects and 264 pairs of age and sex matched, but unrelated, subjects. We calculate the percentages of the concordant and discordant results in each group. Results are compared by using x2 test.Results:
For all related and unrelated groups combined, there were significant differences with mites (der. pteronyssinus, der. farinae) and some moulds (aspergillus mix and rhizopus nigricans) (p < 0.05); When the groups were subdivided into parent-child pairs and same or different sibling pairs, and the same comparisons were made, a significant difference was only found in both sibling pairs (p < 0.05), not in parent-child pairs (p > 0.05). Since there was no both positivity with aspergillus mix and rhizopus nigricans in the two groups, these two allergens were excluded from the study.Conclusion:
It is concluded that we could not say that if one or both of parents are atopic to any allergens, their child will be atopic to the same allergens. Besides, when a respiratory allergy occurs in siblings, only the one who has house dust mite allergy sensitivity can possess the similar antigen sensitivityRESUMEN
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Immunologic Techniques
/
Dermatophagoides pteronyssinus
/
Antigens, Dermatophagoides
/
Allergy and Immunology
/
Hypersensitivity
Type of study:
Prognostic study
/
Risk factors
Limits:
Adult
/
Child
/
Female
/
Humans
/
Male
Language:
English
Journal:
Allergol. immunopatol
Year:
2008
Document type:
Article
Institution/Affiliation country:
Gülhane Military Medical Academy and Medical School/Turkey