Insuficiencia suprarrenal causada por un linfoma no-Hodgking B primario suprarrenal: presentación de un caso y revisión de la literatura / Adrenal failure caused by primary adrenal non-hodking lymphoma: a case report and review of the literature
An. med. interna (Madr., 1983)
; 25(3): 131-133, mar. 2008. ilus
Article
in Es
| IBECS
| ID: ibc-65195
Responsible library:
ES15.1
Localization: ES15.1 - BNCS
RESUMEN
Presentamos el caso de un varón de 78 años que ingresa por un cuadro de debut de insuficiencia suprarrenal. Se realizó un estudio TC que mostró masas suprarrenales bilaterales de hasta 10 cm. Se completó estudio con biopsia percutanea de masa suprarrenal y biopsia de médula ósea, siendo diagnosticado de Linfoma no Hodgkin B difuso de células grandes primario suprarrenal con afectación suprarrenal bilateral. El paciente fue tratado con quimioterapia según esquema R-CHOP (Rituximab, Ciclofosfamida, Doxorrubicina liposomal, Vincristina y Prednisona).Tras 4 ciclos de quimioterapia se objetivo una respuesta parcial radiológica. Se suspendió la quimioterapia por toxicidad grado IV, completándose el tratamiento con RT sobre masa suprarrenal derecha. El paciente falleció por cuadro séptico pocos días después de finalizar la radioterapia, sin objetivarse progresión de la enfermedad
ABSTRACT
We report a case of 78-year old man who presented with symptoms of adrenal insufficiency. The computed tomography (CT) scan showed the presence of bilateral adrenal masses. A CT-scan guided needle biopsy revealed diffuse large- B cell lymphoma. The absence of pathological findings in clinical bone marrow and CT scan examinations supported the diagnosis of Lymphoma of the adrenal glands.The patient was treated with four cycles of R-CHOP chemotherapy with Rituximab, liposomal Doxorubicin, Cyclophosphamide, Vincristine and Prednisolone. At the end of fourth cycle there was radiological improvement but the chemotherapy was stopped because of IV grade toxicity. He completed treatment with radiotherapy of right adrenal mass. Few days after finishing radiation therapy the pacient died due to a disseminated infection. No progressive disease was founded
Search on Google
Collection:
National databases
/
Spain
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Endocrine System Diseases
/
Immune Disorders
/
Lymphomas and Multiple Myeloma
/
Other Malignant Neoplasms
Database:
IBECS
Main subject:
Shock, Septic
/
Biopsy
/
Lymphoma, Non-Hodgkin
/
Addison Disease
/
Adrenocortical Adenoma
/
Diagnosis, Differential
/
Drug Therapy, Combination
Type of study:
Diagnostic study
/
Etiology study
Limits:
Humans
/
Male
Language:
Spanish
Journal:
An. med. interna (Madr., 1983)
Year:
2008
Document type:
Article
Institution/Affiliation country:
Hospital General Universitario Gregorio Marañón/España