Péptidos antihipertensivos derivados de proteínas de leche y huevo / Peptides with antihypertensive activity obtained from milk and egg proteins
Nutr. hosp
; 23(4): 313-318, jul.-ago. 2008. tab
Article
in Es
| IBECS
| ID: ibc-68176
Responsible library:
ES15.1
Localization: ES15.1 - BNCS
RESUMEN
Algunos fragmentos de proteínas alimentarias, una vez liberados mediante hidrólisis, pueden producir un descenso del tono arterial. Son importantes los hidrolizados y péptidos provenientes de proteínas lácteas. Destacan los hidrolizados de caseína con tripsina, y los productos antihipertensivos obtenidos por fermentación de la leche con Lactobacillus helveticus. Estos productos contienen secuencias como Val-Pro-Pro (VPP) e Ile-Pro-Pro (IPP), que inhiben la enzima convertidor a de la angiotensina (ECA). Algunas cepas de Enterococcus faecalis también producen péptidos antihipertensivos inhibidores de la ECA. Entre estos péptidos destaca la secuencia LHLPLP. Existen asimismo péptidos e hidrolizados antihipertensivos derivados de proteínas de huevo. Podemos citar las secuencias FRADHPFL (ovokinina) y RADHPF (ovokinina 2-7) con actividad vasodilatadora endotelio-dependiente, y algunos hidrolizados de clara de huevo que inhibenla ECA. Los productos mencionados podrían utilizarse como ingredientes en alimentos funcionales. Algunos han probado ya su eficacia y seguridad en pacientes hipertensos
ABSTRACT
Antihypertensive hydrolysates and peptides have been isolated from food proteins. Among them, there are of particular interest the antihypertensive casein hydrolysates, and some antihypertensive products obtained when milk was fermented by Lactobacillus helveticus. The sequences Val-Pro-Pro (VPP) and Ile-Pro-Pro (IPP), with angiotensin- converting enzyme (ACE) inhibitory activity, have been isolated from these fermented products. Selected Enterococcus faecalis strains can also produce milk derived peptides with ACE inhibitory and antihypertensive activities. The main of them is the sequence LHLPLP. Some studies also describe the production of antihypertensive hydrolysates and peptides from egg proteins. The sequences FRADHPFL (ovokinin) and RADHPFL (ovokinin 2-7),that have shown endothelium-dependent vasodilator activity, were obtained at first. Some egg white hydrolysates with ACE inhibitory activity have also been described. The idea of including the abovementioned products as functional food ingredients is particularly attractive. Some of them have already proved their safety and effectiveness in hypertensive patients
Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Peptides
/
Hypertension
/
Antihypertensive Agents
Limits:
Humans
Language:
Spanish
Journal:
Nutr. hosp
Year:
2008
Document type:
Article
Institution/Affiliation country:
Natraceutical Group/España
/
Universidad Complutense/España