Protecting antioxidative effects of vitamins E and C in experimental physical stress

ABSTRACT

Like every redox-active compound vitamin E may exert pro-oxidative and antioxidativeeffects depending on the reaction partners present. In this work we evaluatedthe intensity of oxidative stress produced by a physical exercise through swimmingas well as of protecting action of antioxidant vitamins E and C. Antioxidantsystems include antioxidant enzymes superoxide-dismutase (SOD), catalase (CAT),glutathion peroxidase (GSH-Px), as well as of components with an antioxidant actionof the reduced glutathion type (GSH) and vitamins E and C. We determine the activitiesof these enzymes in the erythrocytes and heart homogenate. Our results pointsout a protective effect against oxidative stress produced by swimming in animalstreated with vitamins E and C, which are expressed through the diminution of themalondialdehyde (MDA) quantity both in erythrocytes and in the heart, and throughthe conservation of GSH content in both products. CAT and GSH-Px activitiesdecrease while that of SOD increases on both tissues, but with different intensities inaccordance with the variation of protection degree performed by the vitamin coupleon these tissues. The obtained data underline the necessity of intensifying the meansof endogenous antiradical defence with exogenous antioxidant vitamins C and E.This study highlights the need of a proper vitamin supplement in organism understress (AU)

RESUMEN

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