Serotonin 5-HT1A receptor activation prevents phosphorylation of NMDA receptor NR1 subunit in cerebral ischemia
J. physiol. biochem
; 63(3): 203-212, jul.-sept. 2007. ilus
Article
in En
| IBECS
| ID: ibc-72013
Responsible library:
ES15.1
Localization: ES15.1 - BNCS
ABSTRACT
The mechanisms involved in the neuroprotective effect of serotonin 5-HT1Areceptor agonists on brain damage induced by ischemia remain to be fully elucidated.Given that serotonergic drugs may regulate N-methyl-D-aspartate (NMDA)receptor function, which is implicated in events leading to ischemia-induced neuronalcell death, this study sought to determine the effects of the selective 5-HT1Areceptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), on thelevels of NMDA receptor NR1 subunit in gerbil hippocampus after transient globalcerebral ischemia. Pretreatment with 8-OH-DPAT (1 mg/kg) prevented the neuronalloss in CA1 subfield 72 h after ischemia. NMDA receptor NR1 levels in wholehippocampus were not affected 24 h after ischemia, but the levels of the subunitphosphorylated at the protein kinase A (PKA) site, pNR1(Ser897), were significantlyincreased, and this increase was prevented by the same 8-OH-DPAT dose, a probableconsequence of the increased phosphatase 1 (PP1) enzyme activity found inischemic gerbils pretreated with the 5-HT1A receptor agonist. The results suggestthat NR1 subunit phosphorylation plays a role in the neuroprotective effect of 8-OH-DPAT on cell damage induced by global cerebral ischemia in the gerbil hippocampusand support the potential interest of 5-HT1A receptor activation in the search for neuroprotective strategies (AU)
RESUMEN
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Phosphorylation
/
Serotonin
/
Brain Ischemia
/
Receptors, Serotonin
Limits:
Animals
Language:
English
Journal:
J. physiol. biochem
Year:
2007
Document type:
Article
Institution/Affiliation country:
University of Navarra/España