Alteration of the renal regulatory hormonal pattern during experimental obstructive jaundice
Rev. esp. enferm. dig
; 101(6): 408-412, jun. 2009. tab, ilus
Article
in English
| IBECS
| ID: ibc-74414
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Objective:
the alteration of hormones regulating sodium andwater status is related to renal failure in obstructive jaundice (OJ).Experimentaldesign:
OJ was induced by common bile ductligation. Samples were obtained from the control (SO) and OJgroups at 24 and 72 hours, and at 7 days. Different parametersrelated to biliary obstruction, liver and renal injury, and vasoactivemediators such as renin, aldosterone, endothelin-1 (ET-1) andprostaglandin E2 (PGE2) were studied.Results:
bile duct ligation caused an increase in total bilirubin(p < 0.001) and alkaline phosphatase (AP) (p < 0.001). The SOand OJ groups had the same values for diuresis, renin, and creatinineclearance at 24 h. However, animals with OJ had a lowersodium concentration in urine than SO animals (p < 0.01), as wellas an increase in aldosterone levels (p < 0.03). ANP levels weremoderately increased during OJ but did not reach statistical significancewhen compared to the SO group. In contrast, OJ animalsshowed a rise in serum ET-1 concentration (p < 0.001) and increasedPGE2 in urine (p < 0.001).Conclusions:
biliary obstruction induced an increase in ET-1release and PGE2 urine excretion. These hormones might play arole during the renal complications associated with renal disturbancesthat occur during OJ(AU)
Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Dinoprostone
/
Renin
/
Endothelin-1
/
Jaundice, Obstructive
Type of study:
Etiology study
Limits:
Animals
Language:
English
Journal:
Rev. esp. enferm. dig
Year:
2009
Document type:
Article
Institution/Affiliation country:
Reina Sofía University Hospital/Spain