Surgical management of hereditary colorectal cancer: surgery based on molecular analysis and family history
Rev. esp. enferm. dig
; 101(8): 536-540, ago. 2009. ilus
Article
in English
| IBECS
| ID: ibc-74449
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
The importance of colorectal cancer (CRC) is increasing. Aproportion show a hereditary component, as in Lynch syndromeand Familial Adenomatous Polyposis, and a recently defined entityas well, namely, Familial Colorectal Cancer type X. The highprobability to develop CRC in these groups may, at the time ofrecognition, change surgical management, including its timing oreven the surgical technique. In some cases prophylactic surgerycan play an important role. The possibility of using tools that allowrecognition of the aforementioned syndromes, including microsatelliteinstability, immunohistochemistry for DNA mismatchrepair system proteins, and especially their mutations, is on thebasis of therapeutic strategies that differ from those employed insporadic CRC cases(AU)
Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Rectal Neoplasms
/
Anastomosis, Surgical
/
Biomarkers
/
Colorectal Neoplasms, Hereditary Nonpolyposis
/
Colectomy
/
Colonic Neoplasms
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Rev. esp. enferm. dig
Year:
2009
Document type:
Article
Institution/Affiliation country:
Spanish National Cancer Research Center/Spain
/
12 de Octubre University Hospital/Spain