Bisphosphonate-associated osteonecrosis of the jaw. A proposal for conservative treatment
Med. oral patol. oral cir. bucal (Internet)
; 13(12): 770-773, dic. 2008. ilus
Article
in English
| IBECS
| ID: ibc-76710
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
The use of bisphosphonates (BPs) has proven effective in the treatment of bone-related diseases, despite the potentialrisk of developing osteonecrosis of the jaw (ONJ). So far, results for the treatment of ONJ have not been satisfactory.In our study, we have treated two patients diagnosed with ONJ. In addition to local treatments a hydrogel wasapplied, with promising results. The fistulae disappeared 2-3 weeks into the treatment. After a six-month follow-upperiod there has been no sign of recurrence. The extent of maxillary bone exposure has diminished notably, althoughnot entirely disappeared. In all cases, the patients exhibit no other symptoms (they suffer from no pain or swelling orfunctional impotence). For this reason we believe this protocol might be useful in the case of patients who suffer frompain and fistulation secondary to BP-associated ONJ to improve the state of their lesions until definitive treatmentcan be undertaken.Although these findings are not conclusive, given that we are reporting data on two patients only, we believe thatthis might be an alternative treatment in refractory cases where other therapies are counter-indicated. A controlledrandomized and prospective study would be required to confirm our findings (AU)
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Osteonecrosis
/
Jaw Diseases
/
Diphosphonates
Type of study:
Practice guideline
/
Observational study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Med. oral patol. oral cir. bucal (Internet)
Year:
2008
Document type:
Article
Institution/Affiliation country:
Centro de Ciencias de la Salud/Spain