Estudio de la relación entre las concentraciones plasmáticas de adiponectina, interleucina 18 y ghrelina y la densidad mineral ósea en mujeres con obesidad mórbida tras bypass gástrico / Study of the relationship between adiponectin, interleukin-18, ghrelin and bone mineral density in morbidly obese women after gastric bypass
Endocrinol. nutr. (Ed. impr.)
; 56(7): 355-360, ago.-sept. 2009. ilus, graf
Article
in Spanish
| IBECS
| ID: ibc-76921
Responsible library:
ES1.1
Localization: BNCS
RESUMEN
Objetivo:
Analizar la relación entre adiponectina, interleucina (IL) 18 y ghrelina y la densidad mineral ósea (DMO) en un grupo de mujeres intervenidas 1 año antes de bypass gástrico por obesidad mórbida.Métodos:
Se incluyó a 41 pacientes intervenidas de bypass gástrico, con una media de edad de 46 ± 9 años y un índice de masa corporal (IMC) inicial de 49,5 ± 7,6. Se estudiaron variables antropométricas y de composición corporal por absorciometría mediante rayos X de doble energía (DEXA) y se determinaron, antes y después de la cirugía, las concentraciones plasmáticas de paratirina (PTH), 25(OH)-vitamina D, factor de crecimiento insulínico I (IGF-I), adiponectina, IL-18 y ghrelina. Se analizó la DMO al año del bypass gástrico mediante DEXA.Resultados:
Al año de la cirugía se observó una pérdida del 36,2% del peso inicial, que se asoció a una mejoría del perfil inflamatorio reflejada por una reducción significativa de las concentraciones plasmáticas de IL-18 e incremento de adiponectina. En el estudio univariable la DMO se correlacionó negativamente con la edad (r = -0,287; p = 0,008) y con la masa magra (r = 0,318; p = 0,043), pero no con las concentraciones de adiponectina, IL-18 y ghrelina. Las concentraciones de PTH se correlacionaron positivamente con el peso (r = 0,362; p = 0,030), la masa grasa (r = 0,372; p = 0,039) e inversamente con las concentraciones plasmáticas de calcio (r = -0,48; p = 0,003) y de 25(OH)-vitamina D (r = -0,44; p = 0,014). El calcidiol plasmático se correlacionó negativamente con la suma de masa grasa y masa magra medida por DEXA (r = -0,210; p = 0,043). En el análisis de regresión múltiple, la DMO mantuvo relación únicamente con la masa no grasa (..) (AU)ABSTRACT
Objective:
Analysis of the relationship between adiponectin, interleukin-18 (IL-18) and ghrelin and bone mineral density (BMD), in a group of women that had undergone a gastric- bypass for morbid obesity a year before.Methods:
Forty-one morbidly obese patients aged 46 ± 9 years and with an initial body mass index of 49.5 ± 7.6 were included in the study and a gastric by-pass operation was performed in all of them. Anthropometric variables, body composition measured with dual energy X-ray absorptiometry (DEXA) and plasma concentrations of parathormone (PTH), 25(OH) vitamin D, insulin growth factor (IGF-I), adiponectin, IL-18 and ghrelin were determined before and a year after surgery. BMD was evaluated with DEXA 12 months after bariatric surgery.Results:
A year after surgery 36.2% of inicial body weight was lost and this was associated with an improvement of the inflammatory profile reflected by a significant reduction of IL-18 and a increase of adiponectin plasma concentrations. In the univariate analysis BMD inversely correlated with age (r = -0.287, p = 0.008) and with lean mass (r = 0.318, p = 0.043) but not with adiponectin, IL-18 and ghrelin concentrations. PTH showed a positive correlation with weight (r = 0.362, p = 0.03), lean mass (r = 0.372, p = 0.039), and a negative association with plasma concentrations of calcium (r = -0.48, p = 0.003) and 25(OH) vitamin D (r = -0.44, p = 0.014). Plasma 25(OH) vitamin D correlated negatively with the sum of fat mass and lean mass measured with DEXA (r = -0.210, p = 0.043). In the multiple regression analysis BMD remained associated only with lean mass (â = 0.193, p = 0.016).Conclusions:
Our study does not support the existance of a direct effect of adipose tissue on bone metabolism through the secretion of adiponectin. The absence of association between inflammatory cytokine IL-18 and ghrelin with BMD also argues against their implication in bone regulation (AU)
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Obesity, Morbid
/
Gastric Bypass
/
Bone Density
/
Interleukin-18
/
Adiponectin
/
Ghrelin
Limits:
Female
/
Humans
Language:
Spanish
Journal:
Endocrinol. nutr. (Ed. impr.)
Year:
2009
Document type:
Article
Institution/Affiliation country:
Hospital Universitario Joan XXIII/España
/
Hospital Universitario de Bellvitge/España