The relationship of amelogenesis imperfecta and nephrocalcinosis syndrome

ABSTRACT

Aim: To analyze the prevalence and associated oral findings of nephrocalcinosis in a group of patients affectedwith amelogenesis imperfecta (AI). The relationship between types of AI and nephrocalcinosis were also evaluated.Design: This study examines patients who were referred to Pediatric Dentistry Department of SDU betweenthe years of 2002-2007 and who, upon clinical and radiological examination, were diagnosed with AI and treated.Patients were offered information about the possibility of nephrocalcinosis syndrome. Patients who agreed tohave tests carried out on their renal system were advised to visit the department of nephrology at the clinic. Results:Suspicious radiopacity was observed during renal ultrasonography of a controlled number of patients withhypoplastic type AI. Laboratory results revealed low Ca values (100-300 mg/days) and normal P values (0.4-1.3g/days). Delayed eruption, gingival hyperplasia, pulp stones and orthodontic problems were also observed in thesame patient groups. Conclusion: Although renal findings were observed in a few patients, pediatric dentists arethe doctors who are the first to have early contact with this patient group. Because of the potential risk of nephrocalcinosis,early diagnosis may offer good prognosis (AU)