Papel de pituitary tumour-transforming gene (PTTG) en los adenomas hipofisarios / Rol of Pituitary Tumour-Transforming Gene (PTTG) in the pituitary adenomas
Endocrinol. nutr. (Ed. impr.)
; 57(1): 28-34, ene. 2010. ilus, tab
Article
in Spanish
| IBECS
| ID: ibc-81248
Responsible library:
ES1.1
Localization: BNCS
RESUMEN
El pituitary transforming tumour gene (PTTG) está involucrado en una gran variedad de mecanismos fisiológicos. Se ha descrito sobreexpresión proteínica de PTTG en múltiples neoplasias, como los tumores hipofisarios, la cual favorece la aneuploidía, la inestabilidad genética, la proliferación celular y la angiogénesis, todos ellos procesos clave en la transformación neoplásica. Los estudios llevados a cabo en adenomas hipofisarios indican su asociación con un mayor grado de infiltración y de recidivas. Actualmente se plantea su función potencial como diana terapéutica (AU)
ABSTRACT
The pathogenesis of pituitary tumours is far to be understood. Pituitary transforming tumour gene (PTTG), a gen that induces aneuploidy, genetic instability, cellular proliferation and to stimulate angiogenesis, has been involved in neoplasic transformation and shown overexpressed in many neoplasm as lung, breast, endometrium, thyroid and colon malignant tumours. On the other hand, PTTG has been inconsistently studied in pituitary tumours. The majority of studies have been performed in animals and there is a great variability in the methods used in its determination. The goal of this review is to resume the role of PTTG in tumourogenesis and critically to revise the studies published in humans in order to advance in the knowledge of the pathogenesis of pituitary adenomas and to find clinical useful predictors of the behavior of these tumours (AU)
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Pituitary Neoplasms
/
Neoplasm Proteins
Limits:
Humans
Language:
Spanish
Journal:
Endocrinol. nutr. (Ed. impr.)
Year:
2010
Document type:
Article
Institution/Affiliation country:
Hospital General Universitario de Alicante/España
/
Hospital de Elda/España