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Hemocromatosis neonatal: tratamiento con inmunoglobulinas en la gestación / Neonatal haemochromatosis: treatment with immunoglobulins in pregnancy
Cruceyra Betriu, Mireia; Martínez Sánchez, Nuria; González Arlanzón, M. del Mar; Fernández-Miranda, María de la Calle; Viejo Llorente, Aurora; Frauca Remacha, Esteban; Jara Vega, Paloma; González González, Antonio.
Affiliation
  • Cruceyra Betriu, Mireia; Hospital Universitario La Paz. Madrid. España
  • Martínez Sánchez, Nuria; Hospital Universitario La Paz. Madrid. España
  • González Arlanzón, M. del Mar; Hospital Universitario La Paz. Madrid. España
  • Fernández-Miranda, María de la Calle; Hospital Universitario La Paz. Madrid. España
  • Viejo Llorente, Aurora; Hospital Universitario La Paz. Madrid. España
  • Frauca Remacha, Esteban; Hospital Universitario La Paz. Madrid. España
  • Jara Vega, Paloma; Hospital Universitario La Paz. Madrid. España
  • González González, Antonio; Hospital Universitario La Paz. Madrid. España
Prog. obstet. ginecol. (Ed. impr.) ; 53(9): 377-379, sept. 2010.
Article in Spanish | IBECS | ID: ibc-81862
Responsible library: ES1.1
Localization: BNCS
RESUMEN
La hemocromatosis neonatal (HN) es una enfermedad hepática grave neonatal con alta tasa demortalidad y recurrencia. Se postulaun origen a lo inmunitario, resultado de la presencia de un anticuerpo materno aún por determinar que interfiera con el metabolismo férrico fetal. En esta teoría se basa el tratamiento materno con inmunoglobulinas por vía intravenosa en gestaciones sucesivas. Describimos el caso de una paciente con un hijo anterior diagnosticado y fallecido por HN, que tratamos en la siguiente gestación con inmunoglobulinas por vía intravenosa. Es el primer caso descrito en España y demuestra el éxito de la terapia, tal como describe la literatura científica (AU)
ABSTRACT
Neonatal hemochromatosis is a severe neonatal liver disease with a high mortality and recurrence rate. In theory, it is a gestational alloimmune disease due to there being maternal antibodies against fetal hepatic metabolism. On the basis of this hypothesis, the administration of intravenous immunoglobulin has been reported as a succesful treatment during subsequent pregnancies. Here, we describe the first case of this treatment in Spain which confirms the data available in the literature (AU)
Subject(s)
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Collection: National databases / Spain Health context: SDG3 - Health and Well-Being / SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases Health problem: Target 3.1: Reduce maternal mortality / Target 3.2: Reduce avoidable death in newborns and children under 5 / Digestive System Diseases / Endocrine System Diseases Database: IBECS Main subject: Immunoglobulins / Risk Factors / Hemochromatosis / Liver Diseases Type of study: Etiology study / Prognostic study / Risk factors Limits: Adult / Female / Humans / Male / Infant, Newborn / Pregnancy Language: Spanish Journal: Prog. obstet. ginecol. (Ed. impr.) Year: 2010 Document type: Article Institution/Affiliation country: Hospital Universitario La Paz/España
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Collection: National databases / Spain Health context: SDG3 - Health and Well-Being / SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases Health problem: Target 3.1: Reduce maternal mortality / Target 3.2: Reduce avoidable death in newborns and children under 5 / Digestive System Diseases / Endocrine System Diseases Database: IBECS Main subject: Immunoglobulins / Risk Factors / Hemochromatosis / Liver Diseases Type of study: Etiology study / Prognostic study / Risk factors Limits: Adult / Female / Humans / Male / Infant, Newborn / Pregnancy Language: Spanish Journal: Prog. obstet. ginecol. (Ed. impr.) Year: 2010 Document type: Article Institution/Affiliation country: Hospital Universitario La Paz/España
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