Efecto del clorhidrato de mianserina sobre preparaciones de órgano aislado de cobaya y de rata "in vitro" / Effects of mianserin hydrochloride on isolated organ preparations of guinea-pig and rat "in vitro"
Rev. esp. investig. quir
; 11(3): 101-103, jul.-sept. 2008.
Article
in Spanish
| IBECS
| ID: ibc-87307
Responsible library:
ES1.1
Localization: BNCS
RESUMEN
OBJETIVO. Estudiar las modificaciones inducidas por Mianserina en las respuestas del ileon aislado de cobaya a acetilcolina e histamina, conducto deferente de rata a noradrenalina y útero aislado de rata a histamina. MATERIAL Y MÉTODOS. Se utilizó ileon aislado de cobaya incubado en solución de Tyrode, conducto deferente de rata incubado en solución de Krebs- Henseleit y útero aislado de rata incubado en solución de Jalón. Se realizaron curvas dosis-efecto a acetilcolina, histamina y noradrenalina en ausencia y en presencia de mianserina y se calculó el pA2. RESULTADOS. La mianserina se comporta como antagonista de los neurotransmisores estudiados. Conclusión:
La mianserina se comporta como fármaco escasamente estabilizador inespecífico de membrana (AU)ABSTRACT
OBJETIVE. Study the modifications produced by mianserin in the responses of isolated guinea-pig to acetylcholine and histamine, rat vas deferens to noradrenalinee and rat uterus to histamine. MATERIAL AND METHODS. Guinea-Pig ileum incubated in Tyrode solution were used. Dose-effect curves to acetylcholine and histamine were made in absence and in the presence of mianserin. Rat vas deferens incubated in Krebs-Henseleit solution were used. Dose-effect curves to noradrenaline were made in absence and in the presence of mianserin. Uterus of rat incubated in Jalon solution were used. Dose-effect curves to histamine were made in absence and in the presence of mianserin, pA2 was calculated. RESULTS. Mianserin behave as antagonist of acethylcholine, histamine and noradrenaline. Conclusions:
Mianserin acts as few unspecific membrane stabilizer (AU)
Search on Google
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Ileum
/
Mianserin
Limits:
Animals
Language:
Spanish
Journal:
Rev. esp. investig. quir
Year:
2008
Document type:
Article
Institution/Affiliation country:
Universidad de Salamanca/España
/
Universidad de Valladolid/España