Efecto de amoxapina en preparaciones de órgano aislado de cobaya y de rata "in vitro" / Effect of amoxapine on severa preparations of isolated guinea-pig and rat organ "in vitro"
Rev. esp. investig. quir
; 11(3): 110-112, jul.-sept. 2008.
Article
in Spanish
| IBECS
| ID: ibc-87309
Responsible library:
ES1.1
Localization: BNCS
RESUMEN
OBJETIVO. Estudiar las modificaciones inducidas por amoxapina en las respuestas del íleon aislado de cobaya a acetilcolina e histamina, conducto deferente de rata a noradrenalina y dopamina y útero aislado de rata a histamina. MATERIAL Y MÉTODOS. Se utilizó ileon aislado de cobaya incubado en solución de Tyrode, conducto deferente de rata incubado en solución de Krebs-Henseleit y útero aislado de rata incubado en solución de Jalón. Se realizaron curvas dosis-efecto a acetilcolina, histamina, noradrenalina y dopamina en ausencia y en presencia de amoxapina y se calcularon los valores de pA2 y pD'2. RESULTADOS. La amoxapina se comporta como antagonista de los neurotransmisores estudiados. CONCLUSIONES. La amoxapina se comporta como estabilizador inespecífico de membrana (AU)
ABSTRACT
OBJETIVE. Study the modifications produced by amoxapine in the responses of isolated guinea-pig to acetylcholine and histamine, rat vas deferens to noradrenaline and dopamine and rat uterus to histamine. MATERIAL AND METHODS. Guinea-pig incubated in Tyrode solution were used. Dose-effect curves to acetylcholine and histamine were made in absence and in the presence of amoxapine. Rat vas deferens incubated in Krebs-Henseleit solution were used. Dose-effect to noradrenaline and dopamine were made in the absence and in the presence of amoxapine. Uterus of rat incubated in Jalon solution were used. Dose-effect curves to histamine were made in the absence and in the presence of amoxapine. pA2 and pD'2 were calculated. RESULTS. Amoxapine behave as antagonist of acetylcholine, histamine and dopamine. CONCLUSIONS. Amoxapine acts as unspecific membrane stabilizer (AU)
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Amoxapine
/
Ileum
Limits:
Animals
Language:
Spanish
Journal:
Rev. esp. investig. quir
Year:
2008
Document type:
Article
Institution/Affiliation country:
Instituto de Neurociencias de Castilla y León/España