El neuron-derived orphan receptor-1 previene la apoptosis inducida por la hipoxia en las celulas endoteliales vasculares / NOR-1 prevents vascular endothelial cell apoptosis induced by hypoxia
Clín. investig. arterioscler. (Ed. impr.)
; 22(2): 39-48, mar.-abr. 2010. graf, ilus
Article
in Spanish
| IBECS
| ID: ibc-87691
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Background NOR-1 is a nuclear receptor that is over expressed in human atherosclerotic plaques. This receptor is involved in endothelial cell (EC) growth induced by vascular endothelial growth factor (VEGF) and other mitogens. Our aim was to analyze NOR-1 regulation by hypoxia in EC. Results Hypoxia increased NOR-1 mRNA levels in a time- and dose-dependent manner. Hypoxia-induced NOR-1 expression was prevented by BAPTA-AM (a calcium chelator) but not by inhibitors of p38 MAPK, MEK1/2 (..) (AU)
RESUMEN
Antecedentes El neuron-derived orphan receptor-1 (NOR-1) es un receptor nuclear que esta sobreexpresado en las lesiones ateroscleraticas humanas y que participa en la proliferacion de las celulas endoteliales (CE) en respuesta al factor de crecimiento del endotelial vascular (VEGF) y a otros (..) (AU)
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Cell Hypoxia
/
Apoptosis
/
Endothelial Cells
/
Mitogens
Type of study:
Prognostic study
Limits:
Humans
Language:
Spanish
Journal:
Clín. investig. arterioscler. (Ed. impr.)
Year:
2010
Document type:
Article
Institution/Affiliation country:
ICCC+España