Comparative Investigation on in vitro release of extemporaneously prepared norfloxacin semisolid formulations with marketed silver sulfadiazine 1% cream, USP using model independent approach
Ars pharm
; 51(4): 177-185, oct.-dic. 2010. tab, graf
Article
in English
| IBECS
| ID: ibc-88503
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
ObjectiveIn an attempt for better treatment of bacterial infections, various semisolid formulations containing 5%w/w of norfloxacin were prepared and evaluated for in vitro drug release and in vitro skin permeabilityusing dialysis membrane and rat abdominal skin respectively. The in vitro diffusion and permeationprofile of the prepared formulation was compared with marketed silver sulfadiazine cream 1%, USPusing model independent approach.MethodsVarious semisolid formulations were prepared with different dermatological bases usingstandard procedures. In vitro diffusion and permeation studies were carried out using Keshary-Chein(KC) type diffusion cell using dialysis membrane and rat abdominal skin respectively.ResultsThe f1 lower than 15 and f2 higher than 50 indicated similarities in the in vitro diffusion andpermeation profiles of the extemporaneously prepared selected semisolid formulations and marketedsilver sulfadiazine 1% cream, USP.ConclusionAmongst all the semisolid formulations prepared, carbopol gel base was found to be most suitabledermatological base for norfloxacin, the results obtained for in vitro diffusion, and in vitro skinpermeation studies are comparable with that of marketed silver sulphadiazine 1% cream, USP(AU)
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Norfloxacin
/
Drug Compounding
Limits:
Humans
Language:
English
Journal:
Ars pharm
Year:
2010
Document type:
Article
Institution/Affiliation country:
International Medical University/Malaysia
/
VIT University, Vellore/India