The association between the C677T mutation in the 5.10 methylenetertrahydrofolate reductase gene and deep venous thrombosis in young people
Rev. esp. investig. quir
; 11(4): 137-140, oct.-dic. 2008. tab
Article
in Spanish
| IBECS
| ID: ibc-88978
Responsible library:
ES1.1
Localization: BNCS
RESUMEN
PURPOSE. To evaluate the association between the C677T mutation in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene and deep venous thrombosis (DVT) in young people. METHODS. The prevalence of the C677T mutation in the MTHFR gene was investigated in a population of 97 consecutive and unrelated patients with an objectively documented first episode of DVT under 40 years old and in a control group of 100 healthy subjects, using DNA analysis. FINDINGS. The frequency of genotypes amongst patients was 0.10 TT, 0.44 CT and 0.46 CC and in the control group the results were respectively 0.11, 0.40 and 0.49. The odds ratio (OR) for homozygous genotype 677TT was 1.0 (95% CI 0.4- 2.6), which was not statistically significant (p=0.86). CONCLUSION. In this study, the C677T mutation in the MTHFR gene, including the homozygous mutant genotype, was not associated with an increased risk of deep venous thrombosis in young people (AU)
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Venous Thrombosis
/
Hyperhomocysteinemia
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
Spanish
Journal:
Rev. esp. investig. quir
Year:
2008
Document type:
Article
Institution/Affiliation country:
Molecular Biology Centre/Portugal
/
S. Joño University Hospital/Portual
/
S. Joño University Hospital/Portugal