Increased oxidative stress in children with post infectious Bronchiolitis Obliterans
Allergol. immunopatol
; 39(5): 253-258, sept.-oct. 2011.
Article
in English
| IBECS
| ID: ibc-94352
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Background:
There is increasing evidence that oxidative stress is involved in the development and severity of bronchiolitis obliterans occurring in post-transplant patients. In developing countries, the most common form of bronchiolitis obliterans occurs after severe lung infection, mainly caused by adenovirus. However, the oxidative status in the lungs of children with post infectious bronchiolitis obliterans is unknown.Methods:
The aim of this study was to measure the oxidant (8-isoprostane and protein carbonyls) and antioxidant (catalase and glutathione peroxidase) activity in the bronchoalveolar lavage fluid of 21 children with post-infectious bronchiolitis obliterans, and to correlate oxidant/antioxidant level with lung function. Lung function was assessed by spirometry and plethysmography, one week prior to fiberbronchoscopy.Results:
There was a markedly increased oxidative stress (lipid and protein oxidation) in the bronchoalveolar lavage fluid, and a notorious impairment of lung function demonstrating moderate-severe distal airway narrowing. There was not a significant correlation between the level of oxidants or antioxidants and lung function. There was a consistent antioxidants/oxidants pattern characterised by markedly increased 8-isoprostane and carbonyls, increased GPx and normal catalase activity.Conclusion:
The present study shows for the first time that children with post-infectious bronchiolitis obliterans have a markedly increased oxidative stress in their lungs(AU)
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Bronchoscopy
/
Bronchiolitis Obliterans
/
Bronchoalveolar Lavage Fluid
/
Oxidative Stress
Type of study:
Diagnostic study
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Allergol. immunopatol
Year:
2011
Document type:
Article
Institution/Affiliation country:
Hospital CRS El Pino/Chile
/
University of Santiago de Chile/Chile