Analysis of familial incidence of non-syndromic cleft lip and palate in a Brazilian population
Med. oral patol. oral cir. bucal (Internet)
; 15(6): 898-901, nov. 2010. tab
Article
in English
| IBECS
| ID: ibc-95389
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Background:
The purpose of this study is to follow the familial incidence of non-syndromic or isolated cleft lip,with or without cleft palate (NSCL/P), and to analyze the relation ships between the type of NSCL/P in the affected individual and his/her parent, looking at children in the first grade. Material andMethods:
To investigate the familial incidence of NSCL/P we analyzed the records of 185 patients from 2004-2008, retrospectively. Detailed histories were collected regarding the familial incidence of NSCL/P.For the 185 individuals, the relationship between the type of NSCL/P and the sociodemographic and personal characteristics of the affected person and her/his cleft relatives was obtained.Results:
The individuals were 42 carriers of CL, 109 with CLP (joined in one group) and 34 with CP (p<0.001).Of the total of participants, 65 (35.13%) presented a positive history of cleft in their families and 120 (64.86%)presented a negative history (p<0.001). There were differences between the cleft groups according to types ofcleft and positive familial history (p<0.001). In both groups, the relatives with higher incidence of NSCL/P were cousins, with the same pattern of distribution between the two groups (p=0.175).Conclusions:
Most frequently, fissures result from CL/CLP with no familial history. However, CL/CLP was foundin familial cases and cousins were the relative type more likely to be affected (AU)RESUMEN
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Cleft Lip
/
Cleft Palate
Type of study:
Incidence study
/
Risk factors
Limits:
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Med. oral patol. oral cir. bucal (Internet)
Year:
2010
Document type:
Article
Institution/Affiliation country:
State University of Campinas/Brazil
/
State University of Montes Claros/Brazil
/
University of Alfenas/Brazil