Oral contraceptive use and salivary C-erbB-2, CEA and CA15-3in healthy women: A Case-Control Study
Med. oral patol. oral cir. bucal (Internet)
; 16(1): e29-e32, ene. 2011. tab
Article
in English
| IBECS
| ID: ibc-95835
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Objectives:
Oral contraceptives (OCP) are highly effective, safe and widely used. Higher exposure to endogenous and exogenous estrogens is generally thought to increase the risk of breast cancer. Therefore, this study was conducted to determine if oral contraceptive use affected the expression of CA 15-3, CEA and C-erb B-2 in the saliva of healthy women.Studydesign:
The participants consisted of 87 healthy women (43 controls and 44 using oral contraceptives) ranging in age from 20 to 54 years. The volunteers participated by giving one time stimulated whole saliva samples.Then the samples were analysed for CA 15-3, CEA and C-erb B-2 concentrations.Results:
The student t-test was used to compare group means for variables with comparable variability. The meanof C-erb B-2, CEA, and CA 15-3 concentrations (in the case and control groups) was (1.93, 1.70), (34.46, 31.62) and(12.58, 16.19) respectively. These differences were not statistically significant.Conclusions:
Our findings suggest that the levels of the cancer biomarkers C-erb B-2, CEA and CA 15-3 were not affected by increased levels of estrogens in the body (AU)
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Saliva
/
Carcinoembryonic Antigen
/
Receptor, ErbB-2
/
Mucin-1
/
Contraceptives, Oral
Type of study:
Observational study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
Language:
English
Journal:
Med. oral patol. oral cir. bucal (Internet)
Year:
2011
Document type:
Article
Institution/Affiliation country:
Hamadan University of Medical Sciences/Iran
/
Shaheed Beheshti University of Medical Sciences/Iran