Relationship between hair cadmium levels, indoor ETS exposure and wheezing frequency in children
Allergol. immunopatol
; 40(1): 51-59, ene.-feb. 2012.
Article
in English
| IBECS
| ID: ibc-96259
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Background:
Cadmium (Cd) is a toxic heavy metal and the components of tobacco and scalp hair effectively reflect a long-term environmental exposure.Objective:
The aim of this study was to assess the concentration of Cd levels in the hair of children with recurrent wheezing, and to evaluate the predictors of elevated Cd levels with a focus on anthropometric, environmental, and dietary factors.Methods:
In this case-control study, scalp hair was obtained from 65 children with recurrent wheezing (RW) and from 65 healthy children (HC). Hair Cd concentrations were determined by ICP-MS.Results:
Median (IQR) hair Cd levels were 0.22μg/kg (0.10-0.35) in RW group and 0.12μg/kg (0.04-0.23) in HC group (p=0.013). Multivariable logistic regression model results showed that being a child with RW (OR=6.28; p=0.001), ETS exposure at home (OR=22.56; p<0.001), and mother's education level (OR=0.49; p=0.020), are the major predictor variables for elevated hair Cd levels (cut off >0.17μg/kg). In RW group, multivariable logistic regression results showed that hair Cd levels of >0.17μg/kg was significantly predictive of having three or more wheezing episodes in RW group after adjustment for ETS exposure at home (OR=5.48; p=0.012).Conclusion:
We demonstrated that the more children are exposed to ETS at home, the more they are exposed to heavy metals like Cd. Especially children who have had three or more wheezing attacks over the last six months are much more susceptible than the other asthmatic and non-asthmatic children, and Cd exposure aggravates their asthmatic status(AU)
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Collection:
National databases
/
Spain
Health context:
SDG3 - Target 3.9 Reduce the amount of deaths produced by dangerous chemicals and the pollution of the air, water and soil
Health problem:
Household and Ambient Air Pollution
Database:
IBECS
Main subject:
Cadmium
/
Chemical Pollutants
/
Respiratory Sounds
/
Air Pollution, Indoor
/
Hair
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Child
/
Female
/
Humans
/
Male
Language:
English
Journal:
Allergol. immunopatol
Year:
2012
Document type:
Article
Institution/Affiliation country:
Dışkapı Pediatric Education and Research Hospital/Turkey
/
Kecioren Education and Research Hospital/Turkey