TWIST and p-Akt immunoexpression in normal oral epithelium, oral dysplasia and in oral squamous cell carcinoma
Med. oral patol. oral cir. bucal (Internet)
; 17(1): 29-34, ene. 2012. ilus
Article
in English
| IBECS
| ID: ibc-98913
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Objectives:
The aim of this study was to evaluate the immunoexpression of TWIST and p-Akt proteins in oralleukoplakia (OL) and oral squamous cell carcinoma (OSCC), correlating their expressions with the histological features of the lesions. Studydesign:
Immunohistochemical studies were carried out on 10 normal oral epithelium, 30 OL and 20 OSCC formalin-fixed, paraffin-embedded tissue samples. Immunoperoxidase reactions for TWIST and p-Akt proteins were applied on the specimens and the positivity of the reactions was calculated for 1000 epithelial cells.Results:
Kruskal-Wallis and Dunns post tests revealed a significant difference in TWIST and p-Akt immune expression among normal oral mucosa, OL and OSCC. In addition, a significant positive correlation was found between TWIST and p-Akt expressions according to the Pearsons correlation test.Conclusions:
The results obtained in the current study suggest that TWIST and p-Akt may participate of the multistep process of oral carcinogenesis since its early stages (AU)
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Leukoplakia, Oral
/
Mouth Neoplasms
/
Oncogene Protein v-akt
/
Twist-Related Protein 1
Limits:
Humans
Language:
English
Journal:
Med. oral patol. oral cir. bucal (Internet)
Year:
2012
Document type:
Article
Institution/Affiliation country:
Federal University of Pará/Brazil
/
Piracicaba-UNICAMP/Brazil
/
UNIFOA/Brazil
/
University of Sao Paulo/Brazil
/
University of São Paulo/Brazil