DERL2 (derlin 2) stabilizes BAG6 (BAG cochaperone 6) in chemotherapy resistance of cholangiocarcinoma
J. physiol. biochem
; 80(1): 81-97, Feb. 2024. ilus, graf
Article
in En
| IBECS
| ID: ibc-EMG-567
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
DERL2 (derlin 2) is a critical component of the endoplasmic reticulum quality control pathway system whose mutations play an important role in carcinogenesis, including cholangiocarcinoma (CHOL). However, its role and its underlying mechanism have yet to be elucidated. Herein, we revealed that DERL2 was highly expressed in CHOL and considered as an independent prognostic indicator for inferior survival in CHOL. DERL2 ectopically expressed in CHOL cells promoted cell proliferation and colony formation rates, and depleting DERL2 in CHOL cells curbed tumor growth in vitro and in vivo. More interestingly, the knockout of DERL2 augmented the growth-inhibitory effect of gemcitabine chemotherapy on CHOL cells by inducing cell apoptosis. Mechanistically, we discovered that DERL2 interacted with BAG6 (BAG cochaperone 6), thereby extending its half-life and reinforcing the oncogenic role of BAG6 in CHOL progression. (AU)
Key words
Full text:
1
Collection:
06-national
/
ES
Database:
IBECS
Main subject:
Cholangiocarcinoma
/
Drug Resistance, Neoplasm
/
Drug Therapy
/
Carcinogenesis
/
Genetic Diseases, Inborn
/
Liver Transplantation
/
Cystic Fibrosis Transmembrane Conductance Regulator
/
Cystic Fibrosis
/
Malnutrition
/
Sarcopenia
Type of study:
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Aspects:
Determinantes_sociais_saude
/
Patient_preference
Limits:
Humans
/
Adult
/
Female
/
Male
/
Aged
Country/Region as subject:
Europa
/
Mexico
Language:
En
/
Es
Journal:
J. physiol. biochem
/
An. pediatr. (2003. Ed. impr.)
/
Arch. bronconeumol. (Ed. impr.)
/
Cir. Esp. (Ed. impr.)
/
Nutr. hosp
Year:
2022
/
2023
/
2024
Document type:
Article