High fat diet-induced downregulation of TRPV2 mediates hepatic steatosis via p21 signalling
J. physiol. biochem
; 80(1): 113-126, Feb. 2024. ilus, graf
Article
in English
| IBECS
| ID: ibc-EMG-570
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
The global prevalence and incidence of non-alcoholic fatty liver disease (NAFLD) are exhibiting an increasing trend. NAFLD is characterized by a significant accumulation of lipids, though its underlying mechanism is still unknown. Here we report that high-fat diet (HFD) feeding induced hepatic steatosis in mice, which was accompanied by a reduction in the expression and function of hepatic TRPV2. Moreover, conditional knockout of TRPV2 in hepatocytes exacerbated HFD-induced hepatic steatosis. In an in vitro model of NAFLD, TRPV2 regulated lipid accumulation in HepG2 cells, and TRPV2 activation inhibited the expression of the cellular senescence markers p21 and p16, all of which were mediated by AMPK phosphorylation. Finally, we found that administration of probenecid, a TRPV2 agonist, impaired HFD-induced hepatic steatosis and suppressed HFD-induced elevation in p21 and p16. Collectively, our findings imply that hepatic TRPV2 protects against the accumulation of lipids by modulating p21 signalling. (AU)
Search on Google
Full text:
Available
Collection:
National databases
/
Spain
Health context:
Neglected Diseases
/
SDG3 - Target 3.3 End transmission of communicable diseases
/
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Tuberculosis
/
Tuberculosis
/
Other Respiratory Diseases
Database:
IBECS
Main subject:
Fatty Liver
/
Diet, High-Fat
/
Non-alcoholic Fatty Liver Disease
/
Respiratory Insufficiency
/
Respiratory Tract Infections
/
Blood Cells
/
Body Composition
/
Bone Marrow
/
T-Lymphocytes
/
Absorptiometry, Photon
Type of study:
Etiology study
/
Observational study
/
Prevalence study
/
Prognostic study
/
Risk factors
Limits:
Humans
/
Female
/
Male
/
Adolescent
/
Adult
/
Aged
/
Child
Language:
English
/
Spanish
Journal:
Arch. bronconeumol. (Ed. impr.)
/
J. physiol. biochem
/
An. pediatr. (2003. Ed. impr.)
/
Nutr. hosp
Year:
2023
/
2022
/
2024
Document type:
Article
Institution/Affiliation country:
Guangdong Medical University/China
/
Shenzhen University General Hospital/China
/
Shenzhen University/China
/
Hospital Infantil Universitario Niño Jesús/España
/
Universidad de Sevilla+Spain
/
Institut dInvestigació Germans Trias i Pujol/Spain
/
National Taiwan University Hospital/Taiwan
/
National Yang-Ming University/Taiwan
/
Taipei Veterans General Hospital/Taiwan
/
Universidad Autónoma de Chile/Chile