Single anastomosis duodeno-ileal bypass with sleeve gastrectomy generates sustained improvement of glycemic control compared with sleeve gastrectomy in the diet-induced obese rat model
J. physiol. biochem
; 80(1): 149-160, Feb. 2024. ilus, graf
Article
in English
| IBECS
| ID: ibc-EMG-573
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Bariatric surgery has become a recognized and effective procedure for treating obesity and type 2 diabetes (T2D). Our objective was to directly compare the caloric intake-independent effects of sleeve gastrectomy (SG) and single anastomosis duodenoileal bypass with SG (SADI-S) on glucose tolerance in rats with diet-induced obesity (DIO) and to elucidate the differences between bariatric surgery and caloric restriction. A total of 120 adult male Wistar rats with DIO and insulin resistance were randomly assigned to surgical (sham operation, SG, and SADI-S) and dietary (pair-feeding the amount of food eaten by animals undergoing the SG or SADI-S surgeries) interventions. Body weight and food intake were weekly monitored, and 6 weeks after interventions, fasting plasma glucose, oral glucose and insulin tolerance tests, plasma insulin, adiponectin, GIP, GLP-1, and ghrelin levels were determined. The body weight of SADI-S rats was significantly (p < 0.001) lower as compared to the sham-operated, SG, and pair-fed groups. Furthermore, SADI-S rats exhibited decreased whole body fat mass (p < 0.001), lower food efficiency rates (p < 0.001), and increased insulin sensitivity, as well as improved glucose and lipid metabolism compared to that of the SG and pair-fed rats. SADI-S was more effective than SG, or caloric restriction, in improving glycemic control and metabolic profile, with a higher remission of insulin resistance as well as long-term weight loss. (AU)
Full text:
Available
Collection:
National databases
/
Spain
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Other Respiratory Diseases
/
Trachea, Bronchus, Lung Cancers
Database:
IBECS
Main subject:
Anastomosis, Surgical
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Gastrectomy
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Obesity
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Pleural Diseases
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Nicotiana
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Chest Pain
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Feeding and Eating Disorders
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Adrenal Glands
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Pulmonary Disease, Chronic Obstructive
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Social Media
Type of study:
Controlled clinical trial
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Diagnostic study
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Etiology study
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Incidence study
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Observational study
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Prevalence study
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Prognostic study
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Risk factors
Aspects:
Patient-preference
Limits:
Humans
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Female
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Male
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Adult
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Aged
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Animals
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Child, preschool
Country/Region as subject:
Asia
/
Europa
Language:
English
/
Spanish
Journal:
Arch. bronconeumol. (Ed. impr.)
/
J. physiol. biochem
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An. pediatr. (2003. Ed. impr.)
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Nutr. hosp
Year:
2023
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2022
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2024
Document type:
Article
Institution/Affiliation country:
Instituto de Salud Carlos III/Spain
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Clínica Universidad de Navarra/Spain
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Alexandria University Faculty of Medicine/Egypt
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Alvaro Cunqueiro University Teaching Hospital/Spain
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Ankara University/Turkey
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Brown University School of Public Health/USA
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Complejo Hospitalario de Albacete/Spain
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Gazi University/Turkey
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Health Research Institute of Santiago de Compostela (Instituto de Investigación Sanitaria de Santiago de Compostela IDIS)/Spain
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Hospital Regional Universitario Materno-Infantil/España