Tumor metabolic crosstalk and immunotherapy / Diafonía metabólica tumoral e inmunoterapia
Clin. transl. oncol. (Print)
; 26(4): 797-807, Abr. 2024. ilus
Article
in English
| IBECS
| ID: ibc-VR-44
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
Tumor cells must resist the host's immune system while maintaining growth under harsh conditions of acidity and hypoxia, which indicates that tumors are more robust than normal tissue. Immunotherapeutic agents have little effect on solid tumors, mostly because of the tumor density and the difficulty of penetrating deeply into the tissue to achieve the theoretical therapeutic effect. Various therapeutic strategies targeting the tumor microenvironment (TME) have been developed. Immunometabolic disorders play a dominant role in treatment resistance at both the TME and host levels. Understanding immunometabolic factors and their treatment potential may be a way forward for tumor immunotherapy. Here, we summarize the metabolism of substances that affect tumor progression, the crosstalk between the TME and immunosuppression, and some potential tumor-site targets. We also summarize the progress and challenges of tumor immunotherapy.(AU)
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Full text:
Available
Collection:
National databases
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Spain
Health context:
SDG3 - Target 3C: Increase health financing and the recruitment, development, training and retention of the health workforce
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Sustainable Health Agenda for the Americas
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SDG3 - Health and Well-Being
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Neglected Diseases
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SDG3 - Target 3.3 End transmission of communicable diseases
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SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
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SDG3 - Target 3.2 Reduce avoidable death in newborns and children under 5
Health problem:
Authority and Accountability for Healthcare Workers
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Goal 10: Communicable diseases
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Goal 6: Information systems for health
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Target 3.3: End transmission of communicable diseases
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Target 3.4: Reduce premature mortality due to noncommunicable diseases
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Target 3.2: Reduce avoidable death in newborns and children under 5
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Diarrhea
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COVID-19
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Diarrhoeal Infections
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Pneumonia
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Other Respiratory Diseases
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Infections
Database:
IBECS
Main subject:
Public Health
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Health Personnel
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Knee Injuries
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Pain, Postoperative
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Palliative Care
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Pediatrics
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Pneumonia, Mycoplasma
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Postoperative Care
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Postoperative Period
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Drug Prescriptions
Type of study:
Practice guideline
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Observational study
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Prevalence study
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Prognostic study
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Risk factors
Aspects:
Social determinants of health
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Patient-preference
Limits:
Humans
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Female
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Male
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Aged
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Adolescent
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Animals
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Infant, Newborn
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Pregnancy
Country/Region as subject:
Europa
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South America
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Brazil
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English Caribbean
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Grenada
Language:
Spanish
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English
Journal:
An. pediatr. (2003. Ed. impr.)
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An. sist. sanit. Navar
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Asclepio
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Aten. prim. (Barc., Ed. impr.)
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Clin. transl. oncol. (Print)
/
Metas enferm
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Nutr. hosp
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Psicothema (Oviedo)
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Rehabilitación (Madr., Ed. impr.)
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Rev. Soc. Andal. Traumatol. Ortop. (Ed. impr.)
Year:
2023
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2022
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2021
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2024
Document type:
Article
Institution/Affiliation country:
AELFA-IF Miembro de la IALP, órgano consultivo de la OMS/España
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AMC. Centro Médico Universitario de Ámsterdam/Países Bajos
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Anestesiología, Reanimación y T. Dolor/España
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Asociación de Pacientes con Fallo Intestinal Appetite for Life/Polonia
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Centre Hospitalier Universitaire/Francia
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Centro de Salud Don Benito Oeste/España
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Centro de Salud Sanabria/España
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Centro de Salud Zafra II/España
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Centro de Salud de Isla de Oza/España
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Consorcio Hospital General Universitario de Valencia/España