Myelodysplastic syndromes mortality in Spain: a comprehensive age-period-cohort and joinpoint analysis / Mortalidad por síndromes mielodisplásicos en España: análisis integral de cohortes por períodos de edad y de puntos de unión
Clin. transl. oncol. (Print)
; 26(4): 917-923, Abr. 2024. graf
Article
in English
| IBECS
| ID: ibc-VR-54
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
Objective:
The present study aims to assess the mortality trends in myelodysplastic syndromes (MDS) in Spain from 1980 to 2021.Methods:
Deaths and mid-year population data were collected from the National Institute of Statistics. We estimated age-standardised mortality rates (ASMRs) per 100,000 person-years for all ages and ages 3564. Joinpoint regression identified significant changes in mortality trends. The independent effects of age, period and birth cohort on MDS mortality were also examined.Results:
MDS-related deaths gradually increased from 36 in 1980 to 1118 in 2021, with an overall increase of 6.6% in age-standardised mortality rates (ASMRs) for both men and women. Joinpoint analysis identified four periods for both men and women 19801987 (stable rates), 19871990 (sharp increase), 19901999 (slower increase) and 19992021 (stable rates). ASMRs (3564 years) increased by 2.5% over the study period, with a turning point identified in 1996 when rates decreased. Mortality from MDS increases with age and is higher in men. The cohort's relative risk increased until the mid-1950s and then stabilised, whilst the period relative risk increased between 1982 and 1996 and then stabilised.Conclusion:
The results of this study indicate a progressive increase in MDS-related deaths in Spain between 1980 and 2021. Notably, this increase was more pronounced in men than in women. Analysis of birth cohort trends revealed shifts in MDS risk, characterised by an increase until the mid-twentieth century, followed by a stabilisation. Using joinpoint analysis, four distinct periods were identified, shedding light on the changing patterns of mortality over time. These findings help to shape future research directions and inform public health strategies. They also provide optimism for advances in MDS treatment and potential reductions in mortality.(AU)
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Full text:
Available
Collection:
National databases
/
Spain
Health context:
SDG3 - Target 3.9 Reduce the amount of deaths produced by dangerous chemicals and the pollution of the air, water and soil
/
SDG3 - Health and Well-Being
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Neglected Diseases
Health problem:
Occupational Exposures
/
Target 3.3: End transmission of communicable diseases
/
Diarrhea
/
Neglected Diseases
/
Zoonoses
Database:
IBECS
Main subject:
Coronavirus Infections
/
Pandemics
/
Pediatrics
/
Pelvis
/
Periapical Diseases
/
Periodicals as Topic
/
Peru
/
Professional Competence
/
Quality of Life
/
Rheumatology
Type of study:
Controlled clinical trial
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Diagnostic study
/
Etiology study
/
Practice guideline
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Incidence study
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Observational study
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Prevalence study
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Prognostic study
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Qualitative research
/
Risk factors
Aspects:
Patient-preference
Limits:
Humans
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Female
/
Male
/
Adult
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Adolescent
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Aged
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Child
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Child, preschool
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Infant, Newborn
Country/Region as subject:
Europa
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South America
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Peru
Language:
Spanish
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English
Journal:
An. pediatr. (2003. Ed. impr.)
/
Asclepio
/
Clin. transl. oncol. (Print)
/
Enferm. intensiva (Ed. impr.)
/
Gac. sanit. (Barc., Ed. impr.)
/
Gastroenterol. hepatol. (Ed. impr.)
/
Int. microbiol
/
Med. oral patol. oral cir. bucal (Internet)
/
Nutr. clín. diet. hosp
/
Radiología (Madr., Ed. impr.)
Year:
2023
/
2022
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2021
/
2024
Document type:
Article
Institution/Affiliation country:
Asociación Española de Nefrología Pediátrica/España
/
Centro de Investigaciones y Estudios Superiores en Antropología Social/México
/
Clínica Universidad de Navarra/España
/
Distrito Sanitario Poniente de Almería/España
/
Hainan Key Laboratory for Sustainable Utilization of Tropical Bioresources/China
/
Hospital Clínico Universitario de Ferrol, Ferrol/España
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Hospital Clínico Universitario de Santiago de Compostela/España
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Hospital Clínico Universitario de Santiago/España
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Hospital General Universitario Gregorio Marañón/Spain
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Hospital Severo Ochoa/Spain