Senescence in head and neck squamous cell carcinoma: relationship between senescence-associated secretory phenotype (SASP) mRNA expression level and clinicopathological features / Senescencia en el carcinoma de células escamosas de cabeza y cuello: relación entre el nivel de expresión del ARNm del fenotipo secretor asociado a la senescencia (SASP) y las características clínico-patológicas
Clin. transl. oncol. (Print)
; 26(4): 1022-1032, Abr. 2024. graf
Article
in English
| IBECS
| ID: ibc-VR-65
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
Background:
Cellular senescence is a state characterized by cell-cycle arrest and apoptotic resistance. Senescence in cancer may be induced by oncogenes or therapy. While cellular senescence might play an important role in protection against cancer development, elevated and uncontrolled senescent cells accumulation may promote carcinogenesis by secreting a collection of pro-inflammatory factors, collectively termed the senescence-associated secretory phenotype (SASP). Material andmethods:
We determined the gene expression at mRNA level of selected cellular senescence markers (p16 and LMNB1) and SASP factors (IL-6, IL-1b, CXCL-1 and TNF-α) in 72 cancerous tissues and 64 normal tissues obtained from patients with head and neck squamous cell carcinoma (HNSCC) and correlated this data with patients clinical follow-up.Results:
Our results indicate higher levels of selected SASP factors in cancerous compared to normal tissues. We presented the relationship between SASP factors expression at the transcript level and the progression of the disease. Moreover, we proposed CXCL1 as a candidate biomarker differentiating normal tissues from cancerous ones and IL1b expression as a molecular factor related to increased TNM stage.Conclusion:
Our primary study indicates that SASP expression may be associated with some clinicopathological features. However, a more detailed study is needed to present specific role of senescence-related mechanism and SASPs especially in tumor therapy response and in relation to the patients immune system condition.(AU)
Full text:
Available
Collection:
National databases
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Spain
Health context:
SDG3 - Target 3.7 Universal access to health services related to reproductive and sexual health
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Sustainable Health Agenda for the Americas
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SDG3 - Health and Well-Being
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Neglected Diseases
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SDG3 - Target 3.3 End transmission of communicable diseases
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SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
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SDG3 - Target 3.2 Reduce avoidable death in newborns and children under 5
Health problem:
Violence Against Women and Harmul Practices
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Goal 10: Communicable diseases
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Goal 6: Information systems for health
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Target 3.8 Achieve universal access to health
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Target 3.3: End transmission of communicable diseases
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Target 3.4: Reduce premature mortality due to noncommunicable diseases
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Target 3.2: Reduce avoidable death in newborns and children under 5
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Diarrhea
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Zoonoses
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COVID-19
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Digestive System Diseases
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Gallbladder and Biliary Tract Cancer
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Infections
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Neonatal Healthcare
Database:
IBECS
Main subject:
Pediatrics
/
Social Support
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Bile Ducts
/
Pandemics
/
Gender-Based Violence
/
Phenotype
/
Primary Health Care
/
Psychometrics
/
Audiovisual Aids
/
Social Adjustment
Type of study:
Diagnostic study
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Etiology study
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Evaluation study
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Practice guideline
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Incidence study
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Observational study
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Prevalence study
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Prognostic study
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Qualitative research
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Risk factors
Aspects:
Social determinants of health
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Patient-preference
Limits:
Humans
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Female
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Male
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Adolescent
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Adult
/
Aged
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Child
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Infant, Newborn
Country/Region as subject:
South America
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Argentina
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Africa
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Europa
Language:
Spanish
/
English
Journal:
An. pediatr. (2003. Ed. impr.)
/
Rev. esp. anestesiol. reanim
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Rev. esp. cir. ortop. traumatol. (Ed. impr.)
/
Aten. prim. (Barc., Ed. impr.)
/
Clin. transl. oncol. (Print)
/
Enferm. infecc. microbiol. clín. (Ed. impr.)
/
Gastroenterol. hepatol. (Ed. impr.)
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Int. microbiol
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Interv. psicosoc. (Internet)
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Med. clín (Ed. impr.)
Year:
2022
/
2023
/
2024
/
2021
Document type:
Article
Institution/Affiliation country:
Hospital Universitario Virgen del Rocío/España
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Instituto Valenciano de Pediatría/España
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Centro de Salud Fuente de San Luis/España
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Complexo Hospitalario Universitario de Pontevedra/España
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Fundación Pública Andaluza para la Gestión de la Investigación en Salud de Sevilla (FISEVI)/España
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Galician Health Service/Spain
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Grupo Español de Reanimación Cardiopulmonar Pediátrica y Neonatal/España
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Hospital Arnau de Vilanova/España
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Hospital Clínico Universitario de Santiago de Compostela/España
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Hospital General Universitario Gregorio Marañón de Madrid/España