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Characterization of a Plasmodium falciparum mutant that has deleted the majority of the gametocyte-specific Pf11-1 locus
Mem. Inst. Oswaldo Cruz ; 87(supl.3): 91-4, 1992. tab, ilus
Article in En | LILACS | ID: lil-121081
Responsible library: BR15.1
ABSTRACT
We identified a gametocyte-specific protein of Plasmodium falciparum called Pf11-1 and provide experimental evidence that this molecule is involved in the emergence of gametes of the infected erythrocyte (gametogenesis). A mutant parasite clone, which has deleted over 90% of the PF11-1 gene locus, was an important control to establish the gametocyte-specific expression of the Pf11-1. Molecular analysis of the Pf11-1 deletion indicates that it is presumably due a chromosome breakage with subsequent "healing" by the addition of telomeric heptanucleotides. Moreover, similar DNA rearrangements are observed in most of the laboratory isolates during asexual propagation in vitro
Subject(s)
Full text: 1 Collection: 01-internacional Database: LILACS Main subject: Plasmodium falciparum / Chromosome Deletion / Histocompatibility Antigens Language: En Journal: Mem. Inst. Oswaldo Cruz Journal subject: MEDICINA TROPICAL / PARASITOLOGIA Year: 1992 Document type: Article Country of publication: Brazil
Full text: 1 Collection: 01-internacional Database: LILACS Main subject: Plasmodium falciparum / Chromosome Deletion / Histocompatibility Antigens Language: En Journal: Mem. Inst. Oswaldo Cruz Journal subject: MEDICINA TROPICAL / PARASITOLOGIA Year: 1992 Document type: Article Country of publication: Brazil