Proteoglycans and glycosaminoglycans synthesized by the hepatic granulomas isolated from schistosome-infected mice and by a granuloma-derived connective tissue cell line
Braz. j. med. biol. res
; 27(9): 2283-300, Sept. 1994. tab, graf
Article
in English
| LILACS
| ID: lil-144481
Responsible library:
BR1.1
RESUMO
1. This paper summarizes our studies on proteglycans and glycosaminoglycans in the hepatic fibrosis occurring in schistosomiasis. 2. We have compared proteglycans and glycosaminoglycans isolated from schistosomal fibrotic granulomas with those obtained from the cellular and extracellular compartments of a murine cell line derived from schistosome-induced granulomas, primary cell line "GR". 3. Our results have shown some biochemical and structural similarities between proteglycans and glycosaminoglycans extracted from granulomas and those synthesized and secreted by GR cells, suggesting that cells may be the major cell population involved in synthesis and accumulation of these molecules in the schistosomal periovular granulomas in liver. Furthermore, we have shown that GR cells can function as an extramedullary myelopoietic stroma that mediates a long-term myeloid proliferation through an autocrine mechanism where the interaction between myelopoietic growth factors and cell-surface heparan sulfate proteoglycans was characterized
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Collection:
International databases
Health context:
Neglected Diseases
Health problem:
Neglected Diseases
/
Zoonoses
Database:
LILACS
Main subject:
Proteoglycans
/
Schistosomiasis mansoni
/
Connective Tissue
/
Glycosaminoglycans
/
Granuloma
/
Liver Cirrhosis, Experimental
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1994
Document type:
Article
/
Congress and conference