Inflammatory cutaneous reaction induced by the lectin of Dioclea grandiflora (Mart.)
Mem. Inst. Oswaldo Cruz
; 88(4): 599-603, Oct.-Dec. 1993. ilus, tab
Article
in English
| LILACS
| ID: lil-148848
Responsible library:
BR1.1
RESUMO
The lectin from Dioclea grandiflora (Mart.) that selectively binds glucose and mannose, when subcutaneously injected in mouse induces an inflammatory cutaneous reaction whose histological analysis reveals an hemorrhagic ulceration with exudative reaction accompanied by an influx of polymorphonuclear leukocytes and giant cells. The presence of lymphocytes and plasma cells in the lesion was insignificant. In order to characterize the in vivo action of inflammatory factors generated by this lesion, distinct lines of mice were used high and low antibody responder mice; the genetically selected mice to the acute phase of inflammatory reaction; lines of mice deficient in C5, a protein of the complement system. It is shown that the lectin of D. grandiflora acts as an inflammatory agent probably promoting exocytosis and release of mediators
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Dermatitis, Contact
/
Lectins
Limits:
Animals
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
1993
Document type:
Article