Your browser doesn't support javascript.
loading
Rat limb allotransplantation: efficacy of subtherapeutic dose combination immunotherapy with cyclosporine (CsA) and RS-61443
Ferreira, L. M; Borsanyi, J. P; Benhaim, P; Anthony, J. P; Mathes, S. J; Andrews, J. M; Laredo Filho, J.
Rev. Hosp. Säo Paulo Esc. Paul. Med ; 6(1/2): 15-9, Jan.-Jun. 1995. ilus
Article in English | LILACS | ID: lil-179686
Responsible library: BR1.1
RESUMO
The synergic effect of subtherapeutic doses of cyclosporine and RS-61443 was demonstrated in a vascularized rat hindlimb allotransplantation across a strong histocompatibility barrier (Brown-Norway as donors and Fischer 344 as recipients). Low doses of agents in combination minimized the toxicity while increasing the therapeutic efficacy. All animals showed weight loss during the first 15 days posttransplantation and they regained protective sensation within 45 postoperative days. Only 15.38 per cent of the animals presented complications thrombosis, enteritis, autophagia and disorders of unknown etiology.
Subject(s)
Search on Google
Add to My VHL
Print
XML
Collection: International databases Database: LILACS Main subject: Cyclosporine / Drug Therapy, Combination / Extremities / Graft Rejection / Immunosuppressive Agents / Mycophenolic Acid Type of study: Etiology study Limits: Animals Language: English Journal: Rev. Hosp. Säo Paulo Esc. Paul. Med Journal subject: Medicine Year: 1995 Document type: Article
Search on Google
Add to My VHL
Print
XML
Collection: International databases Database: LILACS Main subject: Cyclosporine / Drug Therapy, Combination / Extremities / Graft Rejection / Immunosuppressive Agents / Mycophenolic Acid Type of study: Etiology study Limits: Animals Language: English Journal: Rev. Hosp. Säo Paulo Esc. Paul. Med Journal subject: Medicine Year: 1995 Document type: Article